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- W2601574496 abstract "Wnt/β-catenin signaling elicits context-dependent transcription switches that determine normal development and oncogenesis. These are mediated by the Wnt enhanceosome, a multiprotein complex binding to the Pygo chromatin reader and acting through TCF/LEF-responsive enhancers. Pygo renders this complex Wnt-responsive, by capturing β-catenin via the Legless/BCL9 adaptor. We used CRISPR/Cas9 genome engineering of Drosophila legless (lgs) and human BCL9 and B9L to show that the C-terminus downstream of their adaptor elements is crucial for Wnt responses. BioID proximity labeling revealed that BCL9 and B9L, like PYGO2, are constitutive components of the Wnt enhanceosome. Wnt-dependent docking of β-catenin to the enhanceosome apparently causes a rearrangement that apposes the BCL9/B9L C-terminus to TCF. This C-terminus binds to the Groucho/TLE co-repressor, and also to the Chip/LDB1-SSDP enhanceosome core complex via an evolutionary conserved element. An unexpected link between BCL9/B9L, PYGO2 and nuclear co-receptor complexes suggests that these β-catenin co-factors may coordinate Wnt and nuclear hormone responses." @default.
- W2601574496 created "2017-04-07" @default.
- W2601574496 creator A5020091361 @default.
- W2601574496 creator A5054629330 @default.
- W2601574496 creator A5061061888 @default.
- W2601574496 creator A5073490352 @default.
- W2601574496 creator A5084496847 @default.
- W2601574496 date "2017-03-15" @default.
- W2601574496 modified "2023-10-16" @default.
- W2601574496 title "Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9" @default.
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- W2601574496 doi "https://doi.org/10.7554/elife.20882" @default.
- W2601574496 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5352222" @default.
- W2601574496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28296634" @default.
- W2601574496 hasPublicationYear "2017" @default.
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