FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2601620906> ?p ?o ?g. }

• W2601620906 endingPage "43" @default.
• W2601620906 startingPage "33" @default.
• W2601620906 abstract "Emergence of multidrug resistant strains of Mycobacterium tuberculosis (MDR-TB) threatens humanity. This problem was complicated by the crisis in development of new anti-tuberculosis antibiotics. Induced reversion of drug resistance seems promising to overcome the problem. Successful clinical trial of a new anti-tuberculosis nanomolecular complex FS-1 has demonstrated prospectively of this approach in combating MDR-TB. Several clinical MDR-TB cultures were isolated from sputum samples prior and in the process of the clinical trial. Every isolate was tested for susceptibility to antibiotics and then they were sequenced for comparative genomics. It was found that the treatment with FS-1 caused an increase in the number of antibiotic susceptible strains among Mtb isolates that was associated with a general increase of genetic heterogeneity of the isolates. Observed impairing of phthiocerol dimycocerosate biosynthesis by disruptive mutations in ppsACD subunits indicated a possible virulence remission for the sake of persistence. It was hypothesized that the FS-1 treatment eradicated the most drug resistant Mtb variants from the population by aggravating the fitness cost of drug resistance mutations. Analysis of distribution of these mutations in the global Mtb population revealed that many of them were incompatible with each other and dependent on allelic states of many other polymorphic loci. The latter discovery may explain the negative correlation between the genetic heterogeneity of the population and the level of drug tolerance. To the best of our knowledge, this work was the first experimental confirmation of the drug induced antibiotic resistance reversion by the induced synergy mechanism that previously was predicted theoretically." @default.
• W2601620906 created "2017-04-07" @default.
• W2601620906 creator A5013573702 @default.
• W2601620906 creator A5016279996 @default.
• W2601620906 creator A5030499792 @default.
• W2601620906 creator A5038332675 @default.
• W2601620906 creator A5055847706 @default.
• W2601620906 creator A5058336661 @default.
• W2601620906 creator A5079610290 @default.
• W2601620906 date "2017-03-22" @default.
• W2601620906 modified "2023-10-17" @default.
• W2601620906 title "Constraints of Drug Resistance in Mycobacterium tuberculosis - Prospects for Pharmacological Reversion of Susceptibility to Antibiotics" @default.
• W2601620906 cites W1537333064 @default.
• W2601620906 cites W1843397982 @default.
• W2601620906 cites W1973428805 @default.
• W2601620906 cites W1973508501 @default.
• W2601620906 cites W1977261026 @default.
• W2601620906 cites W1978084083 @default.
• W2601620906 cites W1991330646 @default.
• W2601620906 cites W2052614567 @default.
• W2601620906 cites W2060248414 @default.
• W2601620906 cites W2066937690 @default.
• W2601620906 cites W2070018389 @default.
• W2601620906 cites W2074503478 @default.
• W2601620906 cites W2082091267 @default.
• W2601620906 cites W2086827484 @default.
• W2601620906 cites W2089462043 @default.
• W2601620906 cites W2090640084 @default.
• W2601620906 cites W2099617791 @default.
• W2601620906 cites W2124853246 @default.
• W2601620906 cites W2125913277 @default.
• W2601620906 cites W2137481485 @default.
• W2601620906 cites W2144529399 @default.
• W2601620906 cites W2151444479 @default.
• W2601620906 cites W2151851241 @default.
• W2601620906 cites W2160143801 @default.
• W2601620906 cites W2163343704 @default.
• W2601620906 cites W2215078144 @default.
• W2601620906 cites W2222642144 @default.
• W2601620906 cites W2306658815 @default.
• W2601620906 cites W2328909818 @default.
• W2601620906 cites W2368099327 @default.
• W2601620906 doi "https://doi.org/10.2174/2210289201708010033" @default.
• W2601620906 hasPublicationYear "2017" @default.
• W2601620906 type Work @default.
• W2601620906 sameAs 2601620906 @default.
• W2601620906 citedByCount "3" @default.
• W2601620906 countsByYear W26016209062017 @default.
• W2601620906 countsByYear W26016209062020 @default.
• W2601620906 countsByYear W26016209062021 @default.
• W2601620906 crossrefType "journal-article" @default.
• W2601620906 hasAuthorship W2601620906A5013573702 @default.
• W2601620906 hasAuthorship W2601620906A5016279996 @default.
• W2601620906 hasAuthorship W2601620906A5030499792 @default.
• W2601620906 hasAuthorship W2601620906A5038332675 @default.
• W2601620906 hasAuthorship W2601620906A5055847706 @default.
• W2601620906 hasAuthorship W2601620906A5058336661 @default.
• W2601620906 hasAuthorship W2601620906A5079610290 @default.
• W2601620906 hasBestOaLocation W26016209061 @default.
• W2601620906 hasConcept C104317684 @default.
• W2601620906 hasConcept C114851261 @default.
• W2601620906 hasConcept C127716648 @default.
• W2601620906 hasConcept C133936738 @default.
• W2601620906 hasConcept C142724271 @default.
• W2601620906 hasConcept C2776301714 @default.
• W2601620906 hasConcept C2777975735 @default.
• W2601620906 hasConcept C2781069245 @default.
• W2601620906 hasConcept C2908647359 @default.
• W2601620906 hasConcept C501593827 @default.
• W2601620906 hasConcept C54355233 @default.
• W2601620906 hasConcept C70883133 @default.
• W2601620906 hasConcept C71924100 @default.
• W2601620906 hasConcept C86803240 @default.
• W2601620906 hasConcept C89423630 @default.
• W2601620906 hasConcept C94665300 @default.
• W2601620906 hasConcept C99454951 @default.
• W2601620906 hasConceptScore W2601620906C104317684 @default.
• W2601620906 hasConceptScore W2601620906C114851261 @default.
• W2601620906 hasConceptScore W2601620906C127716648 @default.
• W2601620906 hasConceptScore W2601620906C133936738 @default.
• W2601620906 hasConceptScore W2601620906C142724271 @default.
• W2601620906 hasConceptScore W2601620906C2776301714 @default.
• W2601620906 hasConceptScore W2601620906C2777975735 @default.
• W2601620906 hasConceptScore W2601620906C2781069245 @default.
• W2601620906 hasConceptScore W2601620906C2908647359 @default.
• W2601620906 hasConceptScore W2601620906C501593827 @default.
• W2601620906 hasConceptScore W2601620906C54355233 @default.
• W2601620906 hasConceptScore W2601620906C70883133 @default.
• W2601620906 hasConceptScore W2601620906C71924100 @default.
• W2601620906 hasConceptScore W2601620906C86803240 @default.
• W2601620906 hasConceptScore W2601620906C89423630 @default.
• W2601620906 hasConceptScore W2601620906C94665300 @default.
• W2601620906 hasConceptScore W2601620906C99454951 @default.
• W2601620906 hasIssue "1" @default.
• W2601620906 hasLocation W26016209061 @default.
• W2601620906 hasOpenAccess W2601620906 @default.
• W2601620906 hasPrimaryLocation W26016209061 @default.
• W2601620906 hasRelatedWork W1985830215 @default.

• next