Matches in SemOpenAlex for { <https://semopenalex.org/work/W2601730734> ?p ?o ?g. }
- W2601730734 endingPage "210" @default.
- W2601730734 startingPage "202" @default.
- W2601730734 abstract "Phenolic compounds in rosemary have shown antiproliferative/cytotoxic activity against colorectal cancer cells. The aim of this work was to study in depth the absorption and metabolism of the compounds present in a rosemary extract. An in-situ perfusion assay was performed in mice, for which samples of gastrointestinal liquid taken at different times and plasma obtained at the end of the experiment were analysed by HPLC-ESI-QTOF-MS. The absorption-rate coefficients showed that flavonoids and diterpenes were highly absorbed compared to triterpenes. Several diterpenes and their metabolites were also bioavailable in plasma, highlighting the higher concentrations of glucuronide metabolites compared to non-metabolised phenolic compounds. The antiproliferative/cytotoxic properties could be attributed to the absorbed diterpenes and metabolites, which could reach the colon through bloodstream. On the other hand, compounds poorly absorbed, such as triterpenes and some diterpenes, could exhibit their bioactivity in the large intestine by a mechanism of direct interaction with the microbiota." @default.
- W2601730734 created "2017-04-07" @default.
- W2601730734 creator A5014550963 @default.
- W2601730734 creator A5028887717 @default.
- W2601730734 creator A5029784262 @default.
- W2601730734 creator A5055581040 @default.
- W2601730734 creator A5061555612 @default.
- W2601730734 creator A5062347407 @default.
- W2601730734 creator A5068784555 @default.
- W2601730734 creator A5081661175 @default.
- W2601730734 date "2017-06-01" @default.
- W2601730734 modified "2023-10-18" @default.
- W2601730734 title "Phenolic compounds in rosemary as potential source of bioactive compounds against colorectal cancer: In situ absorption and metabolism study" @default.
- W2601730734 cites W1032305322 @default.
- W2601730734 cites W1526755650 @default.
- W2601730734 cites W1531664873 @default.
- W2601730734 cites W1964211194 @default.
- W2601730734 cites W1966172926 @default.
- W2601730734 cites W1968875717 @default.
- W2601730734 cites W1973900565 @default.
- W2601730734 cites W1974279037 @default.
- W2601730734 cites W1987370786 @default.
- W2601730734 cites W1989340511 @default.
- W2601730734 cites W1990880803 @default.
- W2601730734 cites W1991480458 @default.
- W2601730734 cites W1991997903 @default.
- W2601730734 cites W1994023284 @default.
- W2601730734 cites W1995082772 @default.
- W2601730734 cites W1995203863 @default.
- W2601730734 cites W2000016625 @default.
- W2601730734 cites W2006481761 @default.
- W2601730734 cites W2019034328 @default.
- W2601730734 cites W2019615063 @default.
- W2601730734 cites W2023391432 @default.
- W2601730734 cites W2023995851 @default.
- W2601730734 cites W2025735354 @default.
- W2601730734 cites W2037399389 @default.
- W2601730734 cites W2038660711 @default.
- W2601730734 cites W2039521152 @default.
- W2601730734 cites W2040435198 @default.
- W2601730734 cites W2043620773 @default.
- W2601730734 cites W2052792986 @default.
- W2601730734 cites W2066795936 @default.
- W2601730734 cites W2069126054 @default.
- W2601730734 cites W2069409746 @default.
- W2601730734 cites W2070047429 @default.
- W2601730734 cites W2075011718 @default.
- W2601730734 cites W2078668912 @default.
- W2601730734 cites W2080304600 @default.
- W2601730734 cites W2080637212 @default.
- W2601730734 cites W2084824965 @default.
- W2601730734 cites W2098441819 @default.
- W2601730734 cites W2102961828 @default.
- W2601730734 cites W2108687798 @default.
- W2601730734 cites W2116984154 @default.
- W2601730734 cites W2132363861 @default.
- W2601730734 cites W2139160199 @default.
- W2601730734 cites W2169480704 @default.
- W2601730734 cites W2396509159 @default.
- W2601730734 cites W2560253919 @default.
- W2601730734 cites W2914676175 @default.
- W2601730734 cites W425890144 @default.
- W2601730734 doi "https://doi.org/10.1016/j.jff.2017.03.046" @default.
- W2601730734 hasPublicationYear "2017" @default.
- W2601730734 type Work @default.
- W2601730734 sameAs 2601730734 @default.
- W2601730734 citedByCount "30" @default.
- W2601730734 countsByYear W26017307342017 @default.
- W2601730734 countsByYear W26017307342018 @default.
- W2601730734 countsByYear W26017307342019 @default.
- W2601730734 countsByYear W26017307342020 @default.
- W2601730734 countsByYear W26017307342021 @default.
- W2601730734 countsByYear W26017307342022 @default.
- W2601730734 countsByYear W26017307342023 @default.
- W2601730734 crossrefType "journal-article" @default.
- W2601730734 hasAuthorship W2601730734A5014550963 @default.
- W2601730734 hasAuthorship W2601730734A5028887717 @default.
- W2601730734 hasAuthorship W2601730734A5029784262 @default.
- W2601730734 hasAuthorship W2601730734A5055581040 @default.
- W2601730734 hasAuthorship W2601730734A5061555612 @default.
- W2601730734 hasAuthorship W2601730734A5062347407 @default.
- W2601730734 hasAuthorship W2601730734A5068784555 @default.
- W2601730734 hasAuthorship W2601730734A5081661175 @default.
- W2601730734 hasConcept C121332964 @default.
- W2601730734 hasConcept C125287762 @default.
- W2601730734 hasConcept C179998833 @default.
- W2601730734 hasConcept C181389837 @default.
- W2601730734 hasConcept C185592680 @default.
- W2601730734 hasConcept C24890656 @default.
- W2601730734 hasConcept C2779186261 @default.
- W2601730734 hasConcept C43617362 @default.
- W2601730734 hasConcept C44937612 @default.
- W2601730734 hasConcept C55493867 @default.
- W2601730734 hasConcept C62231903 @default.
- W2601730734 hasConcept C86803240 @default.
- W2601730734 hasConcept C98274493 @default.
- W2601730734 hasConceptScore W2601730734C121332964 @default.
- W2601730734 hasConceptScore W2601730734C125287762 @default.