Matches in SemOpenAlex for { <https://semopenalex.org/work/W2601897218> ?p ?o ?g. }
- W2601897218 endingPage "1304" @default.
- W2601897218 startingPage "1289" @default.
- W2601897218 abstract "The misfolding of proteins to form amyloid is a key pathological feature of several progressive, and currently incurable, diseases. A mechanistic understanding of the pathway from soluble, native protein to insoluble amyloid is crucial for therapeutic design, and recent efforts have helped to elucidate the key molecular events that trigger protein misfolding. Generally, either global or local structural perturbations occur early in amyloidogenesis to expose aggregation-prone regions of the protein that can then self-associate to form toxic oligomers. Surprisingly, these initiating structural changes are often caused or influenced by protein regions distal to the classically amyloidogenic sequences. Understanding the importance of these distal regions in the pathogenic process has highlighted many remaining knowledge gaps regarding the precise molecular events that occur in classic aggregation pathways. In this review, we discuss how these distal regions can influence aggregation in disease and the recent technical and conceptual advances that have allowed this insight." @default.
- W2601897218 created "2017-04-07" @default.
- W2601897218 creator A5012305164 @default.
- W2601897218 creator A5024721527 @default.
- W2601897218 creator A5026547202 @default.
- W2601897218 creator A5031291111 @default.
- W2601897218 date "2017-05-01" @default.
- W2601897218 modified "2023-09-26" @default.
- W2601897218 title "Amyloidogenicity at a Distance: How Distal Protein Regions Modulate Aggregation in Disease" @default.
- W2601897218 cites W1167896338 @default.
- W2601897218 cites W1194933460 @default.
- W2601897218 cites W1420421568 @default.
- W2601897218 cites W1488587546 @default.
- W2601897218 cites W1495788363 @default.
- W2601897218 cites W1553780630 @default.
- W2601897218 cites W1680110353 @default.
- W2601897218 cites W1768641225 @default.
- W2601897218 cites W1778292657 @default.
- W2601897218 cites W1858825989 @default.
- W2601897218 cites W1867464533 @default.
- W2601897218 cites W1918986430 @default.
- W2601897218 cites W1919767651 @default.
- W2601897218 cites W1927347955 @default.
- W2601897218 cites W1933062072 @default.
- W2601897218 cites W1952105398 @default.
- W2601897218 cites W1952861039 @default.
- W2601897218 cites W1956586853 @default.
- W2601897218 cites W1964439982 @default.
- W2601897218 cites W1965472986 @default.
- W2601897218 cites W1966457778 @default.
- W2601897218 cites W1969366577 @default.
- W2601897218 cites W1973774127 @default.
- W2601897218 cites W1978948444 @default.
- W2601897218 cites W1979964642 @default.
- W2601897218 cites W1980825524 @default.
- W2601897218 cites W1982138826 @default.
- W2601897218 cites W1985297174 @default.
- W2601897218 cites W1985836613 @default.
- W2601897218 cites W1986060177 @default.
- W2601897218 cites W1986625112 @default.
- W2601897218 cites W1991145775 @default.
- W2601897218 cites W1991447441 @default.
- W2601897218 cites W1992187783 @default.
- W2601897218 cites W1993977451 @default.
- W2601897218 cites W1994345812 @default.
- W2601897218 cites W1994454005 @default.
- W2601897218 cites W1995902122 @default.
- W2601897218 cites W1996555743 @default.
- W2601897218 cites W1996565611 @default.
- W2601897218 cites W1997260669 @default.
- W2601897218 cites W1997294033 @default.
- W2601897218 cites W1997335475 @default.
- W2601897218 cites W1997820676 @default.
- W2601897218 cites W2001299940 @default.
- W2601897218 cites W2002283655 @default.
- W2601897218 cites W2002911779 @default.
- W2601897218 cites W2005379695 @default.
- W2601897218 cites W2009890105 @default.
- W2601897218 cites W2010822282 @default.
- W2601897218 cites W2011473770 @default.
- W2601897218 cites W2012689365 @default.
- W2601897218 cites W2012850328 @default.
- W2601897218 cites W2014764365 @default.
- W2601897218 cites W2017453788 @default.
- W2601897218 cites W2021265420 @default.
- W2601897218 cites W2021977313 @default.
- W2601897218 cites W2023245921 @default.
- W2601897218 cites W2023338599 @default.
- W2601897218 cites W2024559246 @default.
- W2601897218 cites W2027442107 @default.
- W2601897218 cites W2028635309 @default.
- W2601897218 cites W2028868321 @default.
- W2601897218 cites W2030985020 @default.
- W2601897218 cites W2031245909 @default.
- W2601897218 cites W2032903886 @default.
- W2601897218 cites W2034057547 @default.
- W2601897218 cites W2035353973 @default.
- W2601897218 cites W2039330525 @default.
- W2601897218 cites W2042904623 @default.
- W2601897218 cites W2046132401 @default.
- W2601897218 cites W2046263328 @default.
- W2601897218 cites W2046680607 @default.
- W2601897218 cites W2048332130 @default.
- W2601897218 cites W2049391304 @default.
- W2601897218 cites W2051130119 @default.
- W2601897218 cites W2051560414 @default.
- W2601897218 cites W2051577979 @default.
- W2601897218 cites W2057894590 @default.
- W2601897218 cites W2058714994 @default.
- W2601897218 cites W2060038717 @default.
- W2601897218 cites W2060354977 @default.
- W2601897218 cites W2060545093 @default.
- W2601897218 cites W2061600637 @default.
- W2601897218 cites W2062406143 @default.
- W2601897218 cites W2063174765 @default.
- W2601897218 cites W2064538498 @default.
- W2601897218 cites W2064791021 @default.
- W2601897218 cites W2065508663 @default.