Matches in SemOpenAlex for { <https://semopenalex.org/work/W2602017171> ?p ?o ?g. }
- W2602017171 endingPage "32" @default.
- W2602017171 startingPage "22" @default.
- W2602017171 abstract "NADPH oxidases of the Nox family are important enzymatic sources of reactive oxygen species (ROS) in the cardiovascular system. Of the 7 members of the Nox family, at least three depend for their activation on specific cytosolic proteins. These are p47phox and its homologue NoxO1 and p67phox and its homologue NoxA1. Also the Rho-GTPase Rac is important but as this protein has many additional functions, it will not be covered here. The Nox1 enzyme is preferentially activated by the combination of NoxO1 with NoxA1, whereas Nox2 gains highest activity with p47phox together with p67phox. As p47phox, different to NoxO1 contains an auto inhibitory region it has to be phosphorylated prior to complex formation. In the cardio-vascular system, all cytosolic Nox proteins are expressed but the evidence for their contribution to ROS production is not well established. Most data have been collected for p47phox, whereas NoxA1 has basically not yet been studied. In this article the specific aspects of cytosolic Nox proteins in the cardiovascular system with respect to Nox activation, their expression and their importance will be reviewed. Finally, it will be discussed whether cytosolic Nox proteins are suitable pharmacological targets to tamper with vascular ROS production." @default.
- W2602017171 created "2017-04-07" @default.
- W2602017171 creator A5013415164 @default.
- W2602017171 creator A5057524424 @default.
- W2602017171 creator A5082251197 @default.
- W2602017171 date "2017-08-01" @default.
- W2602017171 modified "2023-10-01" @default.
- W2602017171 title "Organizers and activators: Cytosolic Nox proteins impacting on vascular function" @default.
- W2602017171 cites W1510406077 @default.
- W2602017171 cites W1532150676 @default.
- W2602017171 cites W1566517566 @default.
- W2602017171 cites W1576643515 @default.
- W2602017171 cites W1666604877 @default.
- W2602017171 cites W1701455335 @default.
- W2602017171 cites W1727958888 @default.
- W2602017171 cites W1946768698 @default.
- W2602017171 cites W1955390946 @default.
- W2602017171 cites W1965158331 @default.
- W2602017171 cites W1965216303 @default.
- W2602017171 cites W1968860507 @default.
- W2602017171 cites W1974997758 @default.
- W2602017171 cites W1975825287 @default.
- W2602017171 cites W1981905227 @default.
- W2602017171 cites W1983116402 @default.
- W2602017171 cites W1983381448 @default.
- W2602017171 cites W1984201510 @default.
- W2602017171 cites W1984433752 @default.
- W2602017171 cites W1984486105 @default.
- W2602017171 cites W1985033865 @default.
- W2602017171 cites W1991488963 @default.
- W2602017171 cites W1992345340 @default.
- W2602017171 cites W1993261341 @default.
- W2602017171 cites W1993750335 @default.
- W2602017171 cites W1994253596 @default.
- W2602017171 cites W1995247596 @default.
- W2602017171 cites W1995686918 @default.
- W2602017171 cites W1996018508 @default.
- W2602017171 cites W1996495070 @default.
- W2602017171 cites W1996700857 @default.
- W2602017171 cites W1996783916 @default.
- W2602017171 cites W1998073026 @default.
- W2602017171 cites W1998700487 @default.
- W2602017171 cites W2003241255 @default.
- W2602017171 cites W2007101253 @default.
- W2602017171 cites W2008204888 @default.
- W2602017171 cites W2011190955 @default.
- W2602017171 cites W2011863986 @default.
- W2602017171 cites W2013106582 @default.
- W2602017171 cites W2014944893 @default.
- W2602017171 cites W2015213000 @default.
- W2602017171 cites W2015327150 @default.
- W2602017171 cites W2020319663 @default.
- W2602017171 cites W2023064969 @default.
- W2602017171 cites W2026517317 @default.
- W2602017171 cites W2026685522 @default.
- W2602017171 cites W2030437438 @default.
- W2602017171 cites W2030548948 @default.
- W2602017171 cites W2034453407 @default.
- W2602017171 cites W2035040393 @default.
- W2602017171 cites W2035123928 @default.
- W2602017171 cites W2037979222 @default.
- W2602017171 cites W2041050431 @default.
- W2602017171 cites W2043628281 @default.
- W2602017171 cites W2046300908 @default.
- W2602017171 cites W2048220093 @default.
- W2602017171 cites W2050719029 @default.
- W2602017171 cites W2052962324 @default.
- W2602017171 cites W2055247780 @default.
- W2602017171 cites W2055370880 @default.
- W2602017171 cites W2056296858 @default.
- W2602017171 cites W2057397798 @default.
- W2602017171 cites W2060273459 @default.
- W2602017171 cites W2064358616 @default.
- W2602017171 cites W2066660579 @default.
- W2602017171 cites W2066990367 @default.
- W2602017171 cites W2067374348 @default.
- W2602017171 cites W2067773703 @default.
- W2602017171 cites W2068403201 @default.
- W2602017171 cites W2069172813 @default.
- W2602017171 cites W2071742337 @default.
- W2602017171 cites W2073974661 @default.
- W2602017171 cites W2080108062 @default.
- W2602017171 cites W2084643121 @default.
- W2602017171 cites W2085015319 @default.
- W2602017171 cites W2085128107 @default.
- W2602017171 cites W2086998282 @default.
- W2602017171 cites W2087125608 @default.
- W2602017171 cites W2087587398 @default.
- W2602017171 cites W2088164656 @default.
- W2602017171 cites W2088204476 @default.
- W2602017171 cites W2090414072 @default.
- W2602017171 cites W2092759252 @default.
- W2602017171 cites W2093563591 @default.
- W2602017171 cites W2096869450 @default.
- W2602017171 cites W2096954246 @default.
- W2602017171 cites W2097082675 @default.
- W2602017171 cites W2097267275 @default.
- W2602017171 cites W2098576019 @default.