FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2602023687> ?p ?o ?g. }

• W2602023687 abstract "The Kampo medicine bofutsushosan (BTS; Pulvis ledebouriellae compositae; Fang Feng Tong Sheng San) has been used as an anti-obesity treatment in overweight patients. In this study, we assessed the underlying physiological changes induced by BTS in obese mice maintained on a high-fat diet. Male ICR mice were fed a 60% kcal fat diet for 5 weeks starting at 4 weeks of age and then fed the same diet with administration of water (control) or aqueous BTS extract (1.0–2.0 g/kg) for 25 days. Body weight, wet weight of isolated white adipose tissue, and obesity-related serum parameters (glucose, lipids, leptin, adiponectin) were measured after treatment. The mRNA expression levels of leptin, adiponectin, and UCP1 in the adipose tissues were determined by quantitative real-time polymerase chain reaction after the first 5 days of treatment. Bofutsushosan (1.5–2.0 g/kg) significantly decreased total body weight and total wet weight of white adipose tissue isolated from subcutaneous (retroperitoneal) and visceral regions (epididymal, mesenteric, and perirenal). At 2.0 g/kg, BTS also decreased total fat mass, visceral fat mass, and ratio of fat mass to body weight as measured by computed tomography, and significantly decreased epididymal adipocyte size after 14 and 25 days’ treatment. Twenty-five days’ treatment lowered serum glucose, insulin, leptin, and triglycerides, and reduced homeostasis model assessment-insulin resistance. Alternatively, 2.0 g/kg BTS significantly increased mRNA levels of adiponectin, leptin, and UCP1 in interscapular brown adipose tissue but not epididymal white adipose tissue after 5 days’ administration. In the early administration period, BTS increased mRNA expression levels of leptin, adiponectin, and UCP1 in brown adipose tissues. With longer administration, BTS improved insulin resistance, and subsequently reduced serum levels of leptin and triglyceride in parallel with decreased visceral white adipose tissue volume and adipocyte size." @default.
• W2602023687 created "2017-04-07" @default.
• W2602023687 creator A5013781849 @default.
• W2602023687 creator A5015118724 @default.
• W2602023687 creator A5034073288 @default.
• W2602023687 creator A5074263145 @default.
• W2602023687 creator A5082930422 @default.
• W2602023687 date "2017-03-27" @default.
• W2602023687 modified "2023-10-18" @default.
• W2602023687 title "Mechanisms for the anti-obesity actions of bofutsushosan in high-fat diet-fed obese mice" @default.
• W2602023687 cites W11753821 @default.
• W2602023687 cites W1502152603 @default.
• W2602023687 cites W1524321743 @default.
• W2602023687 cites W1587875569 @default.
• W2602023687 cites W1657510722 @default.
• W2602023687 cites W1669871566 @default.
• W2602023687 cites W1967572175 @default.
• W2602023687 cites W1972836378 @default.
• W2602023687 cites W1979957210 @default.
• W2602023687 cites W1987597166 @default.
• W2602023687 cites W1987735654 @default.
• W2602023687 cites W2000296249 @default.
• W2602023687 cites W2015013062 @default.
• W2602023687 cites W2033100201 @default.
• W2602023687 cites W2033159113 @default.
• W2602023687 cites W2042293357 @default.
• W2602023687 cites W2047638224 @default.
• W2602023687 cites W2059834379 @default.
• W2602023687 cites W2069497802 @default.
• W2602023687 cites W2069612190 @default.
• W2602023687 cites W2077689225 @default.
• W2602023687 cites W2092839266 @default.
• W2602023687 cites W2106270379 @default.
• W2602023687 cites W2108365604 @default.
• W2602023687 cites W2112972847 @default.
• W2602023687 cites W2113904222 @default.
• W2602023687 cites W2114821999 @default.
• W2602023687 cites W2131915860 @default.
• W2602023687 cites W2132358997 @default.
• W2602023687 cites W2133698718 @default.
• W2602023687 cites W2152001785 @default.
• W2602023687 cites W2160234571 @default.
• W2602023687 cites W2160852563 @default.
• W2602023687 cites W2180950634 @default.
• W2602023687 cites W2185793661 @default.
• W2602023687 cites W2417542636 @default.
• W2602023687 cites W2607031541 @default.
• W2602023687 doi "https://doi.org/10.1186/s13020-017-0129-x" @default.
• W2602023687 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5369197" @default.
• W2602023687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28360931" @default.
• W2602023687 hasPublicationYear "2017" @default.
• W2602023687 type Work @default.
• W2602023687 sameAs 2602023687 @default.
• W2602023687 citedByCount "16" @default.
• W2602023687 countsByYear W26020236872017 @default.
• W2602023687 countsByYear W26020236872018 @default.
• W2602023687 countsByYear W26020236872019 @default.
• W2602023687 countsByYear W26020236872020 @default.
• W2602023687 countsByYear W26020236872021 @default.
• W2602023687 countsByYear W26020236872022 @default.
• W2602023687 countsByYear W26020236872023 @default.
• W2602023687 crossrefType "journal-article" @default.
• W2602023687 hasAuthorship W2602023687A5013781849 @default.
• W2602023687 hasAuthorship W2602023687A5015118724 @default.
• W2602023687 hasAuthorship W2602023687A5034073288 @default.
• W2602023687 hasAuthorship W2602023687A5074263145 @default.
• W2602023687 hasAuthorship W2602023687A5082930422 @default.
• W2602023687 hasBestOaLocation W26020236871 @default.
• W2602023687 hasConcept C126322002 @default.
• W2602023687 hasConcept C134018914 @default.
• W2602023687 hasConcept C151955695 @default.
• W2602023687 hasConcept C171089720 @default.
• W2602023687 hasConcept C194832188 @default.
• W2602023687 hasConcept C2776175234 @default.
• W2602023687 hasConcept C2776782570 @default.
• W2602023687 hasConcept C2777391703 @default.
• W2602023687 hasConcept C2779306644 @default.
• W2602023687 hasConcept C2780613262 @default.
• W2602023687 hasConcept C511355011 @default.
• W2602023687 hasConcept C71924100 @default.
• W2602023687 hasConceptScore W2602023687C126322002 @default.
• W2602023687 hasConceptScore W2602023687C134018914 @default.
• W2602023687 hasConceptScore W2602023687C151955695 @default.
• W2602023687 hasConceptScore W2602023687C171089720 @default.
• W2602023687 hasConceptScore W2602023687C194832188 @default.
• W2602023687 hasConceptScore W2602023687C2776175234 @default.
• W2602023687 hasConceptScore W2602023687C2776782570 @default.
• W2602023687 hasConceptScore W2602023687C2777391703 @default.
• W2602023687 hasConceptScore W2602023687C2779306644 @default.
• W2602023687 hasConceptScore W2602023687C2780613262 @default.
• W2602023687 hasConceptScore W2602023687C511355011 @default.
• W2602023687 hasConceptScore W2602023687C71924100 @default.
• W2602023687 hasIssue "1" @default.
• W2602023687 hasLocation W26020236871 @default.
• W2602023687 hasLocation W26020236872 @default.
• W2602023687 hasLocation W26020236873 @default.
• W2602023687 hasLocation W26020236874 @default.
• W2602023687 hasOpenAccess W2602023687 @default.
• W2602023687 hasPrimaryLocation W26020236871 @default.
• W2602023687 hasRelatedWork W1957106181 @default.

• next