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• W2602078968 startingPage "e1006238" @default.
• W2602078968 abstract "Pathogens often inhabit the body asymptomatically, emerging to cause disease in response to unknown triggers. In the bladder, latent intracellular Escherichia coli reservoirs are regarded as likely origins of recurrent urinary tract infection (rUTI), a problem affecting millions of women worldwide. However, clinically plausible triggers that activate these reservoirs are unknown. Clinical studies suggest that the composition of a woman’s vaginal microbiota influences her susceptibility to rUTI, but the mechanisms behind these associations are unclear. Several lines of evidence suggest that the urinary tract is routinely exposed to vaginal bacteria, including Gardnerella vaginalis, a dominant member of the vaginal microbiota in some women. Using a mouse model, we show that bladder exposure to G. vaginalis triggers E. coli egress from latent bladder reservoirs and enhances the potential for life-threatening outcomes of the resulting E. coli rUTI. Transient G. vaginalis exposures were sufficient to cause bladder epithelial apoptosis and exfoliation and interleukin-1-receptor-mediated kidney injury, which persisted after G. vaginalis clearance from the urinary tract. These results support a broader view of UTI pathogenesis in which disease can be driven by short-lived but powerful urinary tract exposures to vaginal bacteria that are themselves not “uropathogenic” in the classic sense. This “covert pathogenesis” paradigm may apply to other latent infections, (e.g., tuberculosis), or for diseases currently defined as noninfectious because routine culture fails to detect microbes of recognized significance." @default.
• W2602078968 created "2017-04-07" @default.
• W2602078968 creator A5039769184 @default.
• W2602078968 creator A5044814433 @default.
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• W2602078968 date "2017-03-30" @default.
• W2602078968 modified "2023-10-16" @default.
• W2602078968 title "Transient microbiota exposures activate dormant Escherichia coli infection in the bladder and drive severe outcomes of recurrent disease" @default.
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• W2602078968 doi "https://doi.org/10.1371/journal.ppat.1006238" @default.
• W2602078968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5373645" @default.
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• W2602078968 hasPublicationYear "2017" @default.
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