FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2602110595> ?p ?o ?g. }

• W2602110595 abstract "358 Background: To investigate the prognostic value of PD-1 and PD-L1 expression in patients with high-grade upper tract urothelial carcinoma (UTUC). Methods: Tissue microarrays were created using 448 patients from the International UTUC collaboration who underwent extirpative surgery for high-grade UTUC and stained for PD-1 (antibody (AB): NAT105, diluted 1:250 from Ventana) and PD-L1 (AB: E1L3N prediluted from Cell Signaling). PD-1 and PD-L1 expression was assessed in a semi-quantitative fashion and any percentage of staining of the tumor cells (PD-L1) and tumor-infiltrating lymphocytes (PD-1) was considered positive. Univariate (UVA) and multivariate analyses (MVA) were performed to assess independent prognosticators of oncological outcomes. No funding was received. Results: Median age of the cohort was 69.2 years and 56.5% of patients were male. PD-L1 and PD-1 were positive in 24.1% and 37.5% of patients. PD-L1 positivity was associated with favorable pathological stage, where as PD-1 positivity was significantly associated with pelvicalyceal location, lymph node metastases, non-organ confined disease, presence of lymphovascular invasion, sessile architecture, necrosis, concomitant CIS, and history of non-muscle invasive bladder cancer. PD-L1 positivity was not significantly associated with survival outcomes. In Cox regression UVA, PD-1 positivity was associated with worse recurrence-free survival (RFS) (HR 1.5 (95%CI 1.08-2.14, p=0.016)), cancer-specific survival (CSS) (HR 1.5 (95%CI 1.07-2.19, p=0.021)), and overall survival (OS) (HR 1.5 (95%CI 1.10-1.97, p=0.009)). However in MVA, PD-1 positivity was not found to be an independent predictor of RFS, CSS or OS. Conclusions: PD-1 positivity of tumor-infiltrating lymphocytes was associated with adverse pathological criteria and was a significant prognosticator for RFS, CSS and OS on UVA in patients treated with extirpative surgery for high-grade UTUC in a large, multi-institutional cohort. In MVA, the independent prognostic value of PD-1 was not confirmed. PD-L1 positivity was associated with lower tumor stage, but not with other pathological characteristics or survival outcomes." @default.
• W2602110595 created "2017-04-07" @default.
• W2602110595 creator A5017537551 @default.
• W2602110595 creator A5018208869 @default.
• W2602110595 creator A5020529503 @default.
• W2602110595 creator A5024037114 @default.
• W2602110595 creator A5029945438 @default.
• W2602110595 creator A5041923034 @default.
• W2602110595 creator A5049425103 @default.
• W2602110595 creator A5052276814 @default.
• W2602110595 creator A5061266716 @default.
• W2602110595 creator A5061644837 @default.
• W2602110595 creator A5073556374 @default.
• W2602110595 creator A5075648105 @default.
• W2602110595 creator A5078739113 @default.
• W2602110595 creator A5079401169 @default.
• W2602110595 creator A5080037221 @default.
• W2602110595 creator A5081652574 @default.
• W2602110595 creator A5081879304 @default.
• W2602110595 creator A5084907442 @default.
• W2602110595 creator A5088939859 @default.
• W2602110595 creator A5091753897 @default.
• W2602110595 date "2017-02-20" @default.
• W2602110595 modified "2023-09-30" @default.
• W2602110595 title "Prognostic value of PD-1 and PD-L1 expression in patients with high-grade urothelial carcinoma of the upper urinary tract." @default.
• W2602110595 doi "https://doi.org/10.1200/jco.2017.35.6_suppl.358" @default.
• W2602110595 hasPublicationYear "2017" @default.
• W2602110595 type Work @default.
• W2602110595 sameAs 2602110595 @default.
• W2602110595 citedByCount "0" @default.
• W2602110595 crossrefType "journal-article" @default.
• W2602110595 hasAuthorship W2602110595A5017537551 @default.
• W2602110595 hasAuthorship W2602110595A5018208869 @default.
• W2602110595 hasAuthorship W2602110595A5020529503 @default.
• W2602110595 hasAuthorship W2602110595A5024037114 @default.
• W2602110595 hasAuthorship W2602110595A5029945438 @default.
• W2602110595 hasAuthorship W2602110595A5041923034 @default.
• W2602110595 hasAuthorship W2602110595A5049425103 @default.
• W2602110595 hasAuthorship W2602110595A5052276814 @default.
• W2602110595 hasAuthorship W2602110595A5061266716 @default.
• W2602110595 hasAuthorship W2602110595A5061644837 @default.
• W2602110595 hasAuthorship W2602110595A5073556374 @default.
• W2602110595 hasAuthorship W2602110595A5075648105 @default.
• W2602110595 hasAuthorship W2602110595A5078739113 @default.
• W2602110595 hasAuthorship W2602110595A5079401169 @default.
• W2602110595 hasAuthorship W2602110595A5080037221 @default.
• W2602110595 hasAuthorship W2602110595A5081652574 @default.
• W2602110595 hasAuthorship W2602110595A5081879304 @default.
• W2602110595 hasAuthorship W2602110595A5084907442 @default.
• W2602110595 hasAuthorship W2602110595A5088939859 @default.
• W2602110595 hasAuthorship W2602110595A5091753897 @default.
• W2602110595 hasConcept C121608353 @default.
• W2602110595 hasConcept C126322002 @default.
• W2602110595 hasConcept C126894567 @default.
• W2602110595 hasConcept C142724271 @default.
• W2602110595 hasConcept C143998085 @default.
• W2602110595 hasConcept C144301174 @default.
• W2602110595 hasConcept C146357865 @default.
• W2602110595 hasConcept C151730666 @default.
• W2602110595 hasConcept C193270364 @default.
• W2602110595 hasConcept C204232928 @default.
• W2602110595 hasConcept C207886595 @default.
• W2602110595 hasConcept C2777701055 @default.
• W2602110595 hasConcept C2780352672 @default.
• W2602110595 hasConcept C2781053074 @default.
• W2602110595 hasConcept C2993461684 @default.
• W2602110595 hasConcept C3019882237 @default.
• W2602110595 hasConcept C38180746 @default.
• W2602110595 hasConcept C71924100 @default.
• W2602110595 hasConcept C72563966 @default.
• W2602110595 hasConcept C74864618 @default.
• W2602110595 hasConcept C77411442 @default.
• W2602110595 hasConcept C86803240 @default.
• W2602110595 hasConcept C90924648 @default.
• W2602110595 hasConceptScore W2602110595C121608353 @default.
• W2602110595 hasConceptScore W2602110595C126322002 @default.
• W2602110595 hasConceptScore W2602110595C126894567 @default.
• W2602110595 hasConceptScore W2602110595C142724271 @default.
• W2602110595 hasConceptScore W2602110595C143998085 @default.
• W2602110595 hasConceptScore W2602110595C144301174 @default.
• W2602110595 hasConceptScore W2602110595C146357865 @default.
• W2602110595 hasConceptScore W2602110595C151730666 @default.
• W2602110595 hasConceptScore W2602110595C193270364 @default.
• W2602110595 hasConceptScore W2602110595C204232928 @default.
• W2602110595 hasConceptScore W2602110595C207886595 @default.
• W2602110595 hasConceptScore W2602110595C2777701055 @default.
• W2602110595 hasConceptScore W2602110595C2780352672 @default.
• W2602110595 hasConceptScore W2602110595C2781053074 @default.
• W2602110595 hasConceptScore W2602110595C2993461684 @default.
• W2602110595 hasConceptScore W2602110595C3019882237 @default.
• W2602110595 hasConceptScore W2602110595C38180746 @default.
• W2602110595 hasConceptScore W2602110595C71924100 @default.
• W2602110595 hasConceptScore W2602110595C72563966 @default.
• W2602110595 hasConceptScore W2602110595C74864618 @default.
• W2602110595 hasConceptScore W2602110595C77411442 @default.
• W2602110595 hasConceptScore W2602110595C86803240 @default.
• W2602110595 hasConceptScore W2602110595C90924648 @default.
• W2602110595 hasLocation W26021105951 @default.
• W2602110595 hasOpenAccess W2602110595 @default.
• W2602110595 hasPrimaryLocation W26021105951 @default.

• next