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- W2602112212 abstract "Abstract : With no vaccine available, control of gonorrhea is seriously threatened by the evolution of heightened antibiotic resistance. The fluoroquinolone class of antibiotics served as a first-line treatment option for gonorrhea for only a limited period of time due to the proliferation of resistance mutations. Resistance to fluoroquinolones in Neisseria gonorrhoeae is achieved in a two-step process in which mutations in the quinolone resistance-determining regions of the genes encoding GyrA and ParC confer intermediate and full resistance, respectively. A clinically relevant gyrA sub 91/95 mutation was previously demonstrated by our laboratory to confer increased in vivo fitness to N. gonorrhoeae strain FA19, leading us to hypothesize that the resistance-conferring gyrA sub 91/95 mutations are sufficient to alter the in vivo fitness of other N. gonorrhoeae strains. We found that the presence of this allele in two additional strains of N. gonorrhoeae (FA1090 and MS11) not only enhanced in vivo fitness, but did so at a level that was 10-fold higher than that reported in strain FA19. We further speculated that the enhanced in vivo fitness phenotype arose through the altered enzymatic behavior of mutant DNA gyrase, leading to a transcriptional profile better suited for bacterial survival or growth within the host." @default.
- W2602112212 created "2017-04-07" @default.
- W2602112212 creator A5050347067 @default.
- W2602112212 date "2015-01-05" @default.
- W2602112212 modified "2023-09-24" @default.
- W2602112212 title "Insights into the Enhanced in vivo Fitness of Neisseria gonorrhoeae Driven by a Fluoroquinolone Resistance-Conferring Mutant DNA Gyrase" @default.
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- W2602112212 doi "https://doi.org/10.21236/ad1012700" @default.
- W2602112212 hasPublicationYear "2015" @default.
- W2602112212 type Work @default.