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- W2602122012 abstract "Nickel ions are used as enzyme cofactors in organisms from all kingdoms of life, and these essential enzymes catalyze a variety of remarkable chemical reactions. A significant part of this book is devoted to updating our understanding of the biological chemistry of many of these nickel enzymes, including urease, [NiFe]-hydrogenase, carbon monoxide dehydrogenase and acetyl-CoA synthase, coenzyme M reduction, nickel superoxide dismutase, nickel utilizing glyoxylase I, and the most recent addition to this list, lactate racemase. However, as the content of this book underscores, the biology of nickel encompasses many components beyond the enzymes themselves, including multiple types of membrane transporters, metallochaperones, and regulators, which are critical for maintaining and distributing healthy levels of nickel. Moving even further out from the enzymes, a discussion of nickel in biology also includes the overlap of nickel pathways with the systems of other nutritional metals, aspects of human disease including carcinogenesis and pathogenic microorganisms, biogeochemistry, and, finally, potential applications of this information." @default.
- W2602122012 created "2017-04-07" @default.
- W2602122012 creator A5049226429 @default.
- W2602122012 date "2017-04-04" @default.
- W2602122012 modified "2023-09-24" @default.
- W2602122012 title "Introduction to the Biological Chemistry of Nickel" @default.
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- W2602122012 doi "https://doi.org/10.1039/9781788010580-00001" @default.
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