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- W2602172301 endingPage "41" @default.
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- W2602172301 abstract "The chapter describes a brief selection of interactions between nutrition, genetics, and epigenetics. Epigenetics can be considered a “fine tuning” mechanism, which may modulate basal genetic and nutrition-based information. Nutrition and other factors during pregnancy, infancy, and childhood, through epigenetic effects, can result in an increased risk for cancer, metabolic syndrome, diabetes, cardiovascular disease (CVD), and neurodegenerative disease. An excellent example of the impact of nutrition on an intergenerational epigenetic phenomenon is the agouti mouse response to folate and other methyl donors in the diet. The chapter focuses on folate-related metabolism, with some references to other pathways as appropriate, to illustrate situations or types of interactions between these elements. Although many nutrients can contribute to environmental and genetic factors that lead to disease, folate is particularly relevant to epigenetics since it is the major one-carbon donor for methylation reactions. The chapter also focuses on genetic changes that are more common, that may contribute to epigenetic disturbances." @default.
- W2602172301 created "2017-04-07" @default.
- W2602172301 creator A5041648961 @default.
- W2602172301 creator A5076544689 @default.
- W2602172301 date "2017-03-20" @default.
- W2602172301 modified "2023-10-17" @default.
- W2602172301 title "Genetic or nutritional disturbances in folate‐related pathways and epigenetic interactions" @default.
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