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• W2602364608 abstract "6551 Background: Validated scales exist for quality of life assessment in patients with multiple myeloma (MM); however, no existing tool comprehensively assesses disease- and treatment-related symptoms in these patients. The aim of this study was to validate a module of the M. D. Anderson Symptom Inventory developed for patients with MM (MDASI-MM). The MDASI-MM includes 13 core symptoms, 6 interference items, and 7 MM-specific items: constipation, muscle weakness, diarrhea, sore mouth/throat, rash, difficulty concentrating, and bone aches. Methods: The MDASI-MM was administered to 2 cohorts of patients with MM. The first cohort (N=86) consisted of cross-sectional symptom data from patients at the beginning of induction chemotherapy or autologous hematopoietic stem cell transplant (HSCT). This cohort was used to demonstrate i) known-group validity, by detecting differences in groups by performance status; ii) concurrent validity, by correlating selected items and subscales from the MDASI-MM with those from the Short Form Health Survey (SF-12) and the EORTC-QLQC30; and iii) reliability, by computing Cronbach alpha values. The second cohort (N=53) consisted of symptom data collected at 2 points: prior to transplant and 7 days post-HSCT. This cohort was used to demonstrate the sensitivity of the MDASI-MM to detect acute worsening of patients’ symptoms post-HSCT. Results: The MDASI-MM detected significant differences in symptoms and interference levels according to patients’ performance status (P < .001). MDASI-MM scores correlated with those from SF-12 subscales for physical, emotional, cognitive, and social functioning (all P <.001) and with comparable items from the EORTC-QLQC30 (such as pain, fatigue, difficulty concentrating, constipation, and diarrhea, all P < .001). Cronbach alphas were 0.85 for symptom severity and 0.87 for interference. The MDASI-MM’s overall mean scores worsened between pre- and post-HSCT (1.32 vs. 2.55 (range = 0-10), P < .001). Conclusions: The MDASI-MM is a valid, reliable, and concise tool that can be used to quantitatively assess symptom severity and interference in clinical trials and care of MM patients." @default.
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• W2602364608 date "2012-05-20" @default.
• W2602364608 modified "2023-09-27" @default.
• W2602364608 title "Validation of the M. D. Anderson Symptom Inventory multiple myeloma module." @default.
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• W2602364608 doi "https://doi.org/10.1200/jco.2012.30.15_suppl.6551" @default.
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