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- W2602380713 abstract "(Developmental Cell 17, 583–584; November 17, 2009) After completing this Preview, it has come to the author's attention that the protein identified by Gomez and Billadeau, 2009Gomez T.S. Billadeau D.D. A FAM21-containing WASH complex regulates retromer-dependent sorting.Dev. Cell. 2009; 17: 699-711Abstract Full Text Full Text PDF PubMed Scopus (370) Google Scholar as FAM21 is in fact also present in the WASH complex purified by Derivery et al., 2009Derivery E. Sousa C. Gautier J.J. Lombard B. Loew D. Gautreau A. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.Dev. Cell. 2009; 17: 712-723Abstract Full Text Full Text PDF PubMed Scopus (406) Google Scholar, but is designated KIAA0592. It is not clear why FAM21/KIAA0592 does not run at its predicted MW of 160 kDa in the experiments conducted by Gomez and Billadeau, where it ran at 230 kDa, or why Derivery et al. did not see an equivalently sized band. It is possible, however, that FAM21/KIAA0592 is susceptible to degradation and cleavage during the isolation, generating peptide fragments that were identified by MS. In any case, the apparent discrepancy in terms of the composition of the WASH complex is resolved by clarification that both isolation procedures did lead to identification of FAM21/KIAA0592 as a component. Sorting Out Endosomes in the WASHJames E. BearDevelopmental CellNovember 17, 2009In BriefTwo new studies published in this issue of Developmental Cell by Derivery et al. and Gomez and Billadeau reveal that WASH (Wiskott-Aldrich syndrome protein and SCAR homolog) activates Arp2/3 on endosomes and plays a critical role in the fission of tubules that serve as transport intermediates during endosome sorting. Full-Text PDF Open Archive" @default.
- W2602380713 created "2017-04-07" @default.
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- W2602380713 date "2009-12-01" @default.
- W2602380713 modified "2023-09-30" @default.
- W2602380713 title "Sorting Out Endosomes in the WASH" @default.
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- W2602380713 doi "https://doi.org/10.1016/j.devcel.2009.12.005" @default.
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