Matches in SemOpenAlex for { <https://semopenalex.org/work/W2602409178> ?p ?o ?g. }
- W2602409178 endingPage "1146" @default.
- W2602409178 startingPage "1141" @default.
- W2602409178 abstract "A patient with leukocyte adhesion deficiency type 1 (LAD1) had severe periodontitis and an intractable, deep, nonhealing sacral wound. We had previously found a dominant interleukin-23-interleukin-17 signature at inflamed sites in humans with LAD1 and in mouse models of the disorder. Blockade of this pathway in mouse models has resulted in resolution of the immunopathologic condition. We treated our patient with ustekinumab, an antibody that binds the p40 subunit of interleukin-23 and interleukin-12 and thereby blocks the activity of these cytokines, inhibiting interleukin-23-dependent production of interleukin-17. After 1 year of therapy, our patient had resolution of his inflammatory lesions without serious infections or adverse reactions. Inhibition of interleukin-23 and interleukin-17 may have a role in the management of LAD1. (Funded by the National Institute of Allergy and Infectious Diseases and others.)." @default.
- W2602409178 created "2017-04-07" @default.
- W2602409178 creator A5005206087 @default.
- W2602409178 creator A5014119951 @default.
- W2602409178 creator A5029163913 @default.
- W2602409178 creator A5029666369 @default.
- W2602409178 creator A5031863969 @default.
- W2602409178 creator A5035959051 @default.
- W2602409178 creator A5055380756 @default.
- W2602409178 creator A5056552919 @default.
- W2602409178 creator A5067851127 @default.
- W2602409178 creator A5068473640 @default.
- W2602409178 creator A5069417543 @default.
- W2602409178 creator A5082458518 @default.
- W2602409178 creator A5084031628 @default.
- W2602409178 date "2017-03-23" @default.
- W2602409178 modified "2023-10-18" @default.
- W2602409178 title "Interleukin-12 and Interleukin-23 Blockade in Leukocyte Adhesion Deficiency Type 1" @default.
- W2602409178 cites W1600560134 @default.
- W2602409178 cites W1650441004 @default.
- W2602409178 cites W1893391083 @default.
- W2602409178 cites W1980564318 @default.
- W2602409178 cites W1988952956 @default.
- W2602409178 cites W2004945352 @default.
- W2602409178 cites W2085127303 @default.
- W2602409178 cites W2108984264 @default.
- W2602409178 cites W2109682009 @default.
- W2602409178 cites W2110910354 @default.
- W2602409178 cites W2116956799 @default.
- W2602409178 cites W2119007673 @default.
- W2602409178 cites W2123139912 @default.
- W2602409178 cites W2127704524 @default.
- W2602409178 cites W2130117150 @default.
- W2602409178 cites W2159913536 @default.
- W2602409178 cites W2282499633 @default.
- W2602409178 doi "https://doi.org/10.1056/nejmoa1612197" @default.
- W2602409178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5494261" @default.
- W2602409178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28328326" @default.
- W2602409178 hasPublicationYear "2017" @default.
- W2602409178 type Work @default.
- W2602409178 sameAs 2602409178 @default.
- W2602409178 citedByCount "118" @default.
- W2602409178 countsByYear W26024091782017 @default.
- W2602409178 countsByYear W26024091782018 @default.
- W2602409178 countsByYear W26024091782019 @default.
- W2602409178 countsByYear W26024091782020 @default.
- W2602409178 countsByYear W26024091782021 @default.
- W2602409178 countsByYear W26024091782022 @default.
- W2602409178 countsByYear W26024091782023 @default.
- W2602409178 crossrefType "journal-article" @default.
- W2602409178 hasAuthorship W2602409178A5005206087 @default.
- W2602409178 hasAuthorship W2602409178A5014119951 @default.
- W2602409178 hasAuthorship W2602409178A5029163913 @default.
- W2602409178 hasAuthorship W2602409178A5029666369 @default.
- W2602409178 hasAuthorship W2602409178A5031863969 @default.
- W2602409178 hasAuthorship W2602409178A5035959051 @default.
- W2602409178 hasAuthorship W2602409178A5055380756 @default.
- W2602409178 hasAuthorship W2602409178A5056552919 @default.
- W2602409178 hasAuthorship W2602409178A5067851127 @default.
- W2602409178 hasAuthorship W2602409178A5068473640 @default.
- W2602409178 hasAuthorship W2602409178A5069417543 @default.
- W2602409178 hasAuthorship W2602409178A5082458518 @default.
- W2602409178 hasAuthorship W2602409178A5084031628 @default.
- W2602409178 hasBestOaLocation W26024091781 @default.
- W2602409178 hasConcept C126322002 @default.
- W2602409178 hasConcept C170493617 @default.
- W2602409178 hasConcept C203014093 @default.
- W2602409178 hasConcept C2777371288 @default.
- W2602409178 hasConcept C2778468042 @default.
- W2602409178 hasConcept C2778690821 @default.
- W2602409178 hasConcept C36069631 @default.
- W2602409178 hasConcept C71924100 @default.
- W2602409178 hasConcept C74172505 @default.
- W2602409178 hasConceptScore W2602409178C126322002 @default.
- W2602409178 hasConceptScore W2602409178C170493617 @default.
- W2602409178 hasConceptScore W2602409178C203014093 @default.
- W2602409178 hasConceptScore W2602409178C2777371288 @default.
- W2602409178 hasConceptScore W2602409178C2778468042 @default.
- W2602409178 hasConceptScore W2602409178C2778690821 @default.
- W2602409178 hasConceptScore W2602409178C36069631 @default.
- W2602409178 hasConceptScore W2602409178C71924100 @default.
- W2602409178 hasConceptScore W2602409178C74172505 @default.
- W2602409178 hasIssue "12" @default.
- W2602409178 hasLocation W26024091781 @default.
- W2602409178 hasLocation W26024091782 @default.
- W2602409178 hasLocation W26024091783 @default.
- W2602409178 hasLocation W26024091784 @default.
- W2602409178 hasOpenAccess W2602409178 @default.
- W2602409178 hasPrimaryLocation W26024091781 @default.
- W2602409178 hasRelatedWork W1571384054 @default.
- W2602409178 hasRelatedWork W2005863206 @default.
- W2602409178 hasRelatedWork W2051519978 @default.
- W2602409178 hasRelatedWork W2064480570 @default.
- W2602409178 hasRelatedWork W2322088208 @default.
- W2602409178 hasRelatedWork W2410833002 @default.
- W2602409178 hasRelatedWork W2793354926 @default.
- W2602409178 hasRelatedWork W2976012063 @default.
- W2602409178 hasRelatedWork W4235210598 @default.