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• W2602433032 abstract "Simon's two-stage designs are widely used in clinical trials to assess the activity of a new treatment. In practice, it is often the case that the second stage sample size is different from the planned one. For this reason, the critical value for the second stage is no longer valid for statistical inference. Existing approaches for making statistical inference are either based on asymptotic methods or not optimal. We propose an approach to maximize the power of a study while maintaining the type I error rate, where the type I error rate and power are calculated exactly from binomial distributions. The critical values of the proposed approach are numerically searched by an intelligent algorithm over the complete parameter space. It is guaranteed that the proposed approach is at least as powerful as the conditional power approach which is a valid but non-optimal approach. The power gain of the proposed approach can be substantial as compared to the conditional power approach. We apply the proposed approach to a real Phase II clinical trial." @default.
• W2602433032 created "2017-04-07" @default.
• W2602433032 creator A5063680939 @default.
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• W2602433032 date "2017-06-20" @default.
• W2602433032 modified "2023-10-14" @default.
• W2602433032 title "Optimal inference for Simon's two-stage design with over or under enrollment at the second stage" @default.
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• W2602433032 doi "https://doi.org/10.1080/03610918.2017.1307398" @default.
• W2602433032 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6516485" @default.
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