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• W2602444122 endingPage "51" @default.
• W2602444122 startingPage "51" @default.
• W2602444122 abstract "Over the past two decades, enterococci have emerged as an important agent responsible for hospital acquired infection. Several virulence factors contribute to the adherence, colonization, evasion of the host immune response, and pathogenicity and severity of the infection. Enterococcus faecalis is the most common and virulent species causing infections in hospitalized patients. The aim of the present study was to examine the prevalence of genes encoding virulence factors and antimicrobial resistance patterns of E. faecalis strains isolated from hospitalized patients in Shiraz, south west of Iran.A total of 51 E. faecalis isolates from the urine, blood, pleural fluid, peritoneal fluid, eye discharge, endotracheal tube (ETT) and transjugular intrahepatic portosystemic shunt (TIPS) specimens of patients were identified by phenotypic and genotypic methods. Antimicrobial sensitivity tests and detection of virulence factors were performed using standard methods.The efa and asa1 were the most frequently detected gene (100%) among the isolates, followed by esp (94.1%), ace (90.2%), gelE (80.4%), cylA (64.7%), and hyl (51%). More than half of the isolates (52.9%) were high level gentamicin resistant (HLGR). Vancomycin resistance was observed among 23 (45.1%) isolates. The lowest antimicrobial activity was related to erythromycin (3.9%), tetracycline (5.9%) and ciprofloxacin (9.8%). No isolate was found resistant to fosfomycin and linezolid.Our data indicated a high incidence of virulence factors among E. faecalis strains isolated from clinical samples. Colonization of drug resistant virulent isolates in hospital environment may lead to life threatening infection in hospitalized patients. Therefore, infection control procedures should be performed." @default.
• W2602444122 created "2017-04-07" @default.
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• W2602444122 date "2017-01-01" @default.
• W2602444122 modified "2023-10-03" @default.
• W2602444122 title "High Incidence of Virulence Factors Among Clinical<i>Enterococcus faecalis</i>Isolates in Southwestern Iran" @default.
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• W2602444122 doi "https://doi.org/10.3947/ic.2017.49.1.51" @default.
• W2602444122 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5382050" @default.
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