Matches in SemOpenAlex for { <https://semopenalex.org/work/W2602446259> ?p ?o ?g. }
- W2602446259 endingPage "1924" @default.
- W2602446259 startingPage "1912" @default.
- W2602446259 abstract "As cells age and are exposed to genotoxic stress, preservation of the genomic code requires multiple DNA repair pathways to remove single-strand or double-strand breaks. Loss of function somatic genomic aberrations or germline deficiency in genes involved in DNA repair can result in acute cell death or, after a latency period, cellular transformation. Therapeutic exploitation of DNA repair by inhibition of poly (adenosine diphosphate [ADP]) ribose polymerases (PARP), a family of enzymes involved in the repair of single-strand and in some cases double-strand breaks, has become a novel cancer treatment. Although the application of PARP inhibitors (PARPis) initially focused on tumors with BRCA1 or BRCA2 deficiencies, synthetic susceptibilities to PARPis have been expanded due to the identification of tumors with mutations pathways involved in DNA damage repair, in particular those that repair double-strand breaks using homologous recombination (HR). There is an increasing appreciation that genitourinary (GU) malignancies, including bladder cancer and especially prostate cancer, contain subsets of patients with germline and somatic alterations in HR genes that may reflect an increased response to PARPis. In this review, the authors describe the mechanisms and rationale of the use of PARPis in patients with GU cancers, summarize previously reported preclinical and clinical trials, and identify ongoing trials to determine how PARPis and strategies targeted at HR repair can have widespread application in patients with GU cancers. Cancer 2017;123:1912–1924. © 2017 American Cancer Society." @default.
- W2602446259 created "2017-04-07" @default.
- W2602446259 creator A5010551367 @default.
- W2602446259 creator A5025621926 @default.
- W2602446259 creator A5036590460 @default.
- W2602446259 creator A5041126882 @default.
- W2602446259 creator A5070623757 @default.
- W2602446259 date "2017-03-21" @default.
- W2602446259 modified "2023-10-12" @default.
- W2602446259 title "The emerging role of homologous recombination repair and PARP inhibitors in genitourinary malignancies" @default.
- W2602446259 cites W1523531555 @default.
- W2602446259 cites W1578291413 @default.
- W2602446259 cites W1759753426 @default.
- W2602446259 cites W1804915394 @default.
- W2602446259 cites W1848063234 @default.
- W2602446259 cites W1893588230 @default.
- W2602446259 cites W1912177776 @default.
- W2602446259 cites W1929113708 @default.
- W2602446259 cites W1959660762 @default.
- W2602446259 cites W1966749778 @default.
- W2602446259 cites W1970184435 @default.
- W2602446259 cites W1970211011 @default.
- W2602446259 cites W1972769310 @default.
- W2602446259 cites W1973268287 @default.
- W2602446259 cites W1975443386 @default.
- W2602446259 cites W1981232727 @default.
- W2602446259 cites W1982957001 @default.
- W2602446259 cites W1986471561 @default.
- W2602446259 cites W1992332625 @default.
- W2602446259 cites W1992397774 @default.
- W2602446259 cites W2003581594 @default.
- W2602446259 cites W2005958584 @default.
- W2602446259 cites W2006001375 @default.
- W2602446259 cites W2009007206 @default.
- W2602446259 cites W2014150894 @default.
- W2602446259 cites W2014599726 @default.
- W2602446259 cites W2016172704 @default.
- W2602446259 cites W2020945203 @default.
- W2602446259 cites W2032624087 @default.
- W2602446259 cites W2033816200 @default.
- W2602446259 cites W2034024919 @default.
- W2602446259 cites W2037352738 @default.
- W2602446259 cites W2043077219 @default.
- W2602446259 cites W2044209989 @default.
- W2602446259 cites W2046056066 @default.
- W2602446259 cites W2047631844 @default.
- W2602446259 cites W2057706543 @default.
- W2602446259 cites W2059390353 @default.
- W2602446259 cites W2066969492 @default.
- W2602446259 cites W2068523052 @default.
- W2602446259 cites W2072355125 @default.
- W2602446259 cites W2077419786 @default.
- W2602446259 cites W2096136751 @default.
- W2602446259 cites W2098737737 @default.
- W2602446259 cites W2100286172 @default.
- W2602446259 cites W2101562875 @default.
- W2602446259 cites W2105567212 @default.
- W2602446259 cites W2109772731 @default.
- W2602446259 cites W2110790489 @default.
- W2602446259 cites W2111437716 @default.
- W2602446259 cites W2112211663 @default.
- W2602446259 cites W2112241575 @default.
- W2602446259 cites W2113125265 @default.
- W2602446259 cites W2116005493 @default.
- W2602446259 cites W2116179732 @default.
- W2602446259 cites W2116284235 @default.
- W2602446259 cites W2117639046 @default.
- W2602446259 cites W2118498123 @default.
- W2602446259 cites W2124156743 @default.
- W2602446259 cites W2124371549 @default.
- W2602446259 cites W2130078242 @default.
- W2602446259 cites W2130875528 @default.
- W2602446259 cites W2130962687 @default.
- W2602446259 cites W2131670056 @default.
- W2602446259 cites W2135525536 @default.
- W2602446259 cites W2139802796 @default.
- W2602446259 cites W2142658272 @default.
- W2602446259 cites W2142795777 @default.
- W2602446259 cites W2143231076 @default.
- W2602446259 cites W2147111123 @default.
- W2602446259 cites W2151499633 @default.
- W2602446259 cites W2151876400 @default.
- W2602446259 cites W2152061559 @default.
- W2602446259 cites W2155851270 @default.
- W2602446259 cites W2156391988 @default.
- W2602446259 cites W2156442575 @default.
- W2602446259 cites W2159682317 @default.
- W2602446259 cites W2160220971 @default.
- W2602446259 cites W2160305147 @default.
- W2602446259 cites W2160466424 @default.
- W2602446259 cites W2161112598 @default.
- W2602446259 cites W2161405893 @default.
- W2602446259 cites W2166571825 @default.
- W2602446259 cites W2168268248 @default.
- W2602446259 cites W2168396953 @default.
- W2602446259 cites W2168812605 @default.
- W2602446259 cites W2171972386 @default.
- W2602446259 cites W2202440845 @default.