FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2602466337> ?p ?o ?g. }

• W2602466337 endingPage "297" @default.
• W2602466337 startingPage "283" @default.
• W2602466337 abstract "Abstract Adjusting the efficiency of movement in response to environmental cues is an essential integrative characteristic of adaptive locomotion behavior across species. However, the modulatory molecules and the pathways involved are largely unknown. Recently, we demonstrated that in Caenorhabditis elegans, a loss-of-function of the two-pore-domain potassium (K2P) channel TWK-7 causes a fast, coordinated, and persistent forward crawling behavior in which five central aspects of stimulated locomotion—velocity, direction, wave parameters, duration, and straightness—are affected. Here, we isolated the reduction-of-function allele cau1 of the C. elegans gene kin-2 in a forward genetic screen and showed that it phenocopies the locomotor activity and locomotion behavior of twk-7(null) animals. Kin-2 encodes the negative regulatory subunit of protein kinase A (KIN-1/PKA). Consistently, we found that other gain-of-function mutants of the GαS-KIN-1/PKA pathway resemble kin-2(cau1) and twk-7(null) in locomotion phenotype. Using the powerful genetics of the C. elegans system in combination with cell type-specific approaches and detailed locomotion analyses, we identified TWK-7 as a putative downstream target of the GαS-KIN-1/PKA pathway at the level of the γ-aminobutyric acid (GABA)ergic D-type motor neurons. Due to this epistatic interaction, we suggest that KIN-1/PKA and TWK-7 may share a common pathway that is probably involved in the modulation of both locomotor activity and locomotion behavior during forward crawling." @default.
• W2602466337 created "2017-04-07" @default.
• W2602466337 creator A5039597324 @default.
• W2602466337 creator A5053794426 @default.
• W2602466337 creator A5066342591 @default.
• W2602466337 date "2017-05-01" @default.
• W2602466337 modified "2023-09-24" @default.
• W2602466337 title "Locomotion Behavior Is Affected by the GαS Pathway and the Two-Pore-Domain K+ Channel TWK-7 Interacting in GABAergic Motor Neurons in <i>Caenorhabditis elegans</i>" @default.
• W2602466337 cites W1573973507 @default.
• W2602466337 cites W1811382317 @default.
• W2602466337 cites W1904905451 @default.
• W2602466337 cites W1944127002 @default.
• W2602466337 cites W1954391111 @default.
• W2602466337 cites W1971126847 @default.
• W2602466337 cites W1973951644 @default.
• W2602466337 cites W1977530219 @default.
• W2602466337 cites W1977925481 @default.
• W2602466337 cites W1983581429 @default.
• W2602466337 cites W1991091954 @default.
• W2602466337 cites W1992241459 @default.
• W2602466337 cites W1992722025 @default.
• W2602466337 cites W1996706359 @default.
• W2602466337 cites W1997667243 @default.
• W2602466337 cites W1999837788 @default.
• W2602466337 cites W2000646355 @default.
• W2602466337 cites W2009821005 @default.
• W2602466337 cites W2009912939 @default.
• W2602466337 cites W2009945174 @default.
• W2602466337 cites W2014196290 @default.
• W2602466337 cites W2015311494 @default.
• W2602466337 cites W2016910258 @default.
• W2602466337 cites W2018430478 @default.
• W2602466337 cites W2018824728 @default.
• W2602466337 cites W2021349900 @default.
• W2602466337 cites W2022508149 @default.
• W2602466337 cites W2024045070 @default.
• W2602466337 cites W2027261517 @default.
• W2602466337 cites W2031655872 @default.
• W2602466337 cites W2032203375 @default.
• W2602466337 cites W2035897803 @default.
• W2602466337 cites W2041294372 @default.
• W2602466337 cites W2041532203 @default.
• W2602466337 cites W2050424005 @default.
• W2602466337 cites W2050953282 @default.
• W2602466337 cites W2052305668 @default.
• W2602466337 cites W2054860264 @default.
• W2602466337 cites W2061821143 @default.
• W2602466337 cites W2066951249 @default.
• W2602466337 cites W2069280878 @default.
• W2602466337 cites W2076156388 @default.
• W2602466337 cites W2078580028 @default.
• W2602466337 cites W2081841874 @default.
• W2602466337 cites W2082907094 @default.
• W2602466337 cites W2084450234 @default.
• W2602466337 cites W2089172525 @default.
• W2602466337 cites W2094573634 @default.
• W2602466337 cites W2100272988 @default.
• W2602466337 cites W2100642038 @default.
• W2602466337 cites W2105112945 @default.
• W2602466337 cites W2106835371 @default.
• W2602466337 cites W2108024591 @default.
• W2602466337 cites W2115682148 @default.
• W2602466337 cites W2117553655 @default.
• W2602466337 cites W2120156745 @default.
• W2602466337 cites W2123662215 @default.
• W2602466337 cites W2123663032 @default.
• W2602466337 cites W2124697178 @default.
• W2602466337 cites W2126622254 @default.
• W2602466337 cites W2127307813 @default.
• W2602466337 cites W2127777086 @default.
• W2602466337 cites W2130088507 @default.
• W2602466337 cites W2130852586 @default.
• W2602466337 cites W2131597783 @default.
• W2602466337 cites W2132213368 @default.
• W2602466337 cites W2133351202 @default.
• W2602466337 cites W2144433748 @default.
• W2602466337 cites W2146977442 @default.
• W2602466337 cites W2152075254 @default.
• W2602466337 cites W2153134824 @default.
• W2602466337 cites W2154059764 @default.
• W2602466337 cites W2154113997 @default.
• W2602466337 cites W2155590606 @default.
• W2602466337 cites W2155881793 @default.
• W2602466337 cites W2157194890 @default.
• W2602466337 cites W2159891593 @default.
• W2602466337 cites W2164529434 @default.
• W2602466337 cites W2168082814 @default.
• W2602466337 cites W4230659712 @default.
• W2602466337 cites W2516999368 @default.
• W2602466337 doi "https://doi.org/10.1534/genetics.116.195669" @default.
• W2602466337 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5419475" @default.
• W2602466337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28341653" @default.
• W2602466337 hasPublicationYear "2017" @default.
• W2602466337 type Work @default.
• W2602466337 sameAs 2602466337 @default.
• W2602466337 citedByCount "11" @default.
• W2602466337 countsByYear W26024663372020 @default.
• W2602466337 countsByYear W26024663372021 @default.

• next