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- W2602499985 abstract "The enterohepatic circulation of bile acids (BAs) is governed by specific transporters expressed in the liver and the intestine and plays a critical role in the digestion of fats and oils. During this process, the majority of the BAs secreted from the liver is reabsorbed in intestinal epithelial cells via the apical sodium-dependent bile acid transporter (ASBT/SLC10A2) and then transported into the portal vein. Previous studies revealed that regulation of the ASBT involves BAs and cholesterol. In addition, abnormal ASBT expression and function might lead to some diseases associated with disorders in the enterohepatic circulation of BAs and cholesterol homeostasis, such as diarrhoea and gallstones. However, decreasing cholesterol or BAs by partly inhibiting ASBT-mediated transport might be used for treatments of hypercholesterolemia, cholestasis and diabetes. This review mainly discusses the regulation of the ASBT by BAs and cholesterol and its relevance to diseases and treatment." @default.
- W2602499985 created "2017-04-07" @default.
- W2602499985 creator A5048693726 @default.
- W2602499985 creator A5067132196 @default.
- W2602499985 date "2017-10-01" @default.
- W2602499985 modified "2023-09-25" @default.
- W2602499985 title "An important intestinal transporter that regulates the enterohepatic circulation of bile acids and cholesterol homeostasis: The apical sodium-dependent bile acid transporter (SLC10A2/ASBT)" @default.
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- W2602499985 cites W1554164117 @default.
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- W2602499985 cites W1679376632 @default.
- W2602499985 cites W1826937932 @default.
- W2602499985 cites W1836306145 @default.
- W2602499985 cites W1887870071 @default.
- W2602499985 cites W1964408814 @default.
- W2602499985 cites W1979543957 @default.
- W2602499985 cites W1980661784 @default.
- W2602499985 cites W1982655352 @default.
- W2602499985 cites W1984050494 @default.
- W2602499985 cites W1984859454 @default.
- W2602499985 cites W1992305758 @default.
- W2602499985 cites W2002667678 @default.
- W2602499985 cites W2007705439 @default.
- W2602499985 cites W2009789367 @default.
- W2602499985 cites W2015846619 @default.
- W2602499985 cites W2019275209 @default.
- W2602499985 cites W2021394453 @default.
- W2602499985 cites W2022073300 @default.
- W2602499985 cites W2023431257 @default.
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- W2602499985 cites W2054462517 @default.
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- W2602499985 doi "https://doi.org/10.1016/j.clinre.2017.02.001" @default.
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