Matches in SemOpenAlex for { <https://semopenalex.org/work/W2602499995> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2602499995 abstract "Independent of their beneficial effects on hypertension and cardiovascular related disease, angiotensin receptor type 1 (AT1R) blockers can improve stress-related symptoms. AT1R receptor-mediated actions can be counteracted directly or indirectly by the angiotensin receptor type 2 receptor (AT2R). Our recent studies in a mouse model of PTSD have shown that AT1R blockade increases the extinction (learned inhibition) of a traumatic fear memory and that AT1R mRNA expression is reduced in fear related brain regions of animals treated with the AT1R antagonist losartan. These data imply that downstream AT1 signaling events maybe important in consolidation of fear memory extinction. Therefore we investigated the acute effects of AT2R inhibition and AT2R stimulation on fear memory and baseline anxiety in mice. We performed classical Pavlovian fear conditioning pairing auditory cues with foot shocks and examined fear extinction (% freezing to conditioned stimulus) in the presence of the AT2R antagonist PD 123319 and agonist Compound 21. Twenty-four hours following fear conditioning, PD 123319 (15 mg/kg IP), Compound 21 (10 mg/kg IP) or vehicle was administered prior to fear memory extinction. The PD treated group exhibited significantly less percent freezing (68%; 68 of 100) compared to vehicle control (47%; 47 of 100) during fear expression (F10, 300 = 1.9; p<0.05, n=15) while no effect was observed during extinction retention, an index of long-term fear memory. On the other hand, Compound 21 had no effect on fear expression, extinction or basal levels of anxiety. Moreover, following fear conditioning, qPCR data revealed that mRNA expression of AT2R and angiotensin converting enzyme 2 (ACE2) in the central amygdala were elevated (5 fold and 3 fold respectively, P<0.05, n=6) compared to home cage control, however the AT1R and angiotensin converting enzyme (ACE) gene expression pathways were unaltered. PD 123319 and Compound 21 had no effect on basal levels of anxiety as determined by open field testing. These data indicate that AT1R and AT2R may have divergent effects on short and long-term fear memory formation. Further studies are required to understand the differential regulation of angiotensin receptor signaling in PTSD." @default.
- W2602499995 created "2017-04-07" @default.
- W2602499995 creator A5014153124 @default.
- W2602499995 creator A5056307238 @default.
- W2602499995 creator A5060115160 @default.
- W2602499995 creator A5075079881 @default.
- W2602499995 creator A5087386034 @default.
- W2602499995 date "2015-09-01" @default.
- W2602499995 modified "2023-09-26" @default.
- W2602499995 title "Abstract P201: Divergent Angiotensin Receptor Signaling in a Mouse Model of Post-Traumatic Stress Disorder (PTSD)" @default.
- W2602499995 doi "https://doi.org/10.1161/hyp.66.suppl_1.p201" @default.
- W2602499995 hasPublicationYear "2015" @default.
- W2602499995 type Work @default.
- W2602499995 sameAs 2602499995 @default.
- W2602499995 citedByCount "0" @default.
- W2602499995 crossrefType "journal-article" @default.
- W2602499995 hasAuthorship W2602499995A5014153124 @default.
- W2602499995 hasAuthorship W2602499995A5056307238 @default.
- W2602499995 hasAuthorship W2602499995A5060115160 @default.
- W2602499995 hasAuthorship W2602499995A5075079881 @default.
- W2602499995 hasAuthorship W2602499995A5087386034 @default.
- W2602499995 hasConcept C100798922 @default.
- W2602499995 hasConcept C101991246 @default.
- W2602499995 hasConcept C126322002 @default.
- W2602499995 hasConcept C134018914 @default.
- W2602499995 hasConcept C15744967 @default.
- W2602499995 hasConcept C16837860 @default.
- W2602499995 hasConcept C169760540 @default.
- W2602499995 hasConcept C170493617 @default.
- W2602499995 hasConcept C185592680 @default.
- W2602499995 hasConcept C199289684 @default.
- W2602499995 hasConcept C2776885963 @default.
- W2602499995 hasConcept C2778938600 @default.
- W2602499995 hasConcept C2779144063 @default.
- W2602499995 hasConcept C2780288358 @default.
- W2602499995 hasConcept C2781069985 @default.
- W2602499995 hasConcept C2781161787 @default.
- W2602499995 hasConcept C2908929049 @default.
- W2602499995 hasConcept C48455012 @default.
- W2602499995 hasConcept C71924100 @default.
- W2602499995 hasConceptScore W2602499995C100798922 @default.
- W2602499995 hasConceptScore W2602499995C101991246 @default.
- W2602499995 hasConceptScore W2602499995C126322002 @default.
- W2602499995 hasConceptScore W2602499995C134018914 @default.
- W2602499995 hasConceptScore W2602499995C15744967 @default.
- W2602499995 hasConceptScore W2602499995C16837860 @default.
- W2602499995 hasConceptScore W2602499995C169760540 @default.
- W2602499995 hasConceptScore W2602499995C170493617 @default.
- W2602499995 hasConceptScore W2602499995C185592680 @default.
- W2602499995 hasConceptScore W2602499995C199289684 @default.
- W2602499995 hasConceptScore W2602499995C2776885963 @default.
- W2602499995 hasConceptScore W2602499995C2778938600 @default.
- W2602499995 hasConceptScore W2602499995C2779144063 @default.
- W2602499995 hasConceptScore W2602499995C2780288358 @default.
- W2602499995 hasConceptScore W2602499995C2781069985 @default.
- W2602499995 hasConceptScore W2602499995C2781161787 @default.
- W2602499995 hasConceptScore W2602499995C2908929049 @default.
- W2602499995 hasConceptScore W2602499995C48455012 @default.
- W2602499995 hasConceptScore W2602499995C71924100 @default.
- W2602499995 hasIssue "suppl_1" @default.
- W2602499995 hasLocation W26024999951 @default.
- W2602499995 hasOpenAccess W2602499995 @default.
- W2602499995 hasPrimaryLocation W26024999951 @default.
- W2602499995 hasRelatedWork W1489737221 @default.
- W2602499995 hasRelatedWork W1984829191 @default.
- W2602499995 hasRelatedWork W2157398019 @default.
- W2602499995 hasRelatedWork W2280499766 @default.
- W2602499995 hasRelatedWork W2763129795 @default.
- W2602499995 hasRelatedWork W2895128755 @default.
- W2602499995 hasRelatedWork W2973980956 @default.
- W2602499995 hasRelatedWork W2989479224 @default.
- W2602499995 hasRelatedWork W2016137511 @default.
- W2602499995 hasRelatedWork W2556876443 @default.
- W2602499995 hasVolume "66" @default.
- W2602499995 isParatext "false" @default.
- W2602499995 isRetracted "false" @default.
- W2602499995 magId "2602499995" @default.
- W2602499995 workType "article" @default.