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- W2602555940 abstract "10571 Background: Gemcitabine is used in many solid tumors as a sensitizer for radiation therapy. We sought to determine the maximum tolerated dose (MTD) of gemcitabine when given concurrently with preoperative external beam radiation (EBRT) for patients with high-risk extremity and trunk soft tissue sarcoma (STS). Methods: Fifty gray of EBRT was given in 25 daily fractions over 5 weeks. Gemcitabine was administered on days 1, 8, 22, 29, 43, and 50 at a starting dose of 400 mg/m2. Dose escalation between cohorts by increments of 100 mg/m2 was done using a toxicity severity weight method (TSWM), incorporating 6 different toxicities (Table). This method is a Bayesian procedure that repeatedly assesses the data to find the drug dose having a posterior total toxicity burden closest to a predetermined clinician-defined target (Bekele and Thall, 2004). Clinicopathologic and outcome data were also collected. Results: Thirty-six patients completed the study. Mean tumor size was 6.3 cm and 67% of patients had high..." @default.
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- W2602555940 date "2014-05-20" @default.
- W2602555940 modified "2023-09-26" @default.
- W2602555940 title "Phase I study of neoadjuvant gemcitabine combined with radiation therapy for patients with high-risk extremity and trunk soft tissue sarcomas." @default.
- W2602555940 doi "https://doi.org/10.1200/jco.2014.32.15_suppl.10571" @default.
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