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• W2602623333 abstract "To the Editor: I warmly thank Drs Aronowitz and Grimard for their interest in the story of Despeignes ( 1 Aronowitz J. Grimard L. Regard to Foray. Intl J Radiat Biol Phys. 2017; 97: 1107-1108 Abstract Full Text Full Text PDF Scopus (1) Google Scholar ). I fully agree with them that the technical characteristics of the radiation therapy conducted by Despeignes must be analyzed with caution. The determination of “the most probable scenario of irradiation” invoked in the article ( 2 Foray N. Victor despeignes, the forgotten pioneer of radiation oncology. Int J Radiat Oncol Biol Phys. 2016; 96: 717-721 Abstract Full Text Full Text PDF PubMed Scopus (16) Google Scholar ) was made through simulation studies performed with oncologists and physicists and published in French in my first biography of Despeignes (Table 1) ( 3 Foray N. Victor Despeignes (1866-1937): How a hygienist became the first radiation oncologist. Cancer Radiother. 2013; 17: 244-254 Crossref PubMed Scopus (15) Google Scholar ). Its major conclusions follow. Table 1Simulations of different irradiation treatments for Despeignes' experiment Source: Foray 2013 3 Foray N. Victor Despeignes (1866-1937): How a hygienist became the first radiation oncologist. Cancer Radiother. 2013; 17: 244-254 Crossref PubMed Scopus (15) Google Scholar . Scenario Distance (cm) source–tumor Dose (Gy) at skin surface per session and (total) ∗ The treatment was 2 sessions per day for 19 days. Dose (Gy) at 3 cm skin per session and (total) ∗ The treatment was 2 sessions per day for 19 days. Relevant scenario with interruption or decrease of x-rays production † With less than 21 Gy at the skin and more than 2 Gy in 3 cm depth. 18 kV: 5-mm spark; 0.666 mA; 112 mGy to 1 m per session; depth rate at 3 cm: 2% 10 11.2 (425) ‡ Very probable dermatitis (>20 Gy). 0.22 (8.5) NoToo high dose at skinToo low dose in depth 20 2.8 (106) ‡ Very probable dermatitis (>20 Gy). 0.056 (2.12) 30 1.24 (47) ‡ Very probable dermatitis (>20 Gy). 0.024 (0.94) § Very probable lack of therapeutic efficiency even for a radiosensitive tumor (<2 Gy). 40 0.7 (26) ‡ Very probable dermatitis (>20 Gy). 0.014 (0.53) § Very probable lack of therapeutic efficiency even for a radiosensitive tumor (<2 Gy). 30 kV: 8-mm spark; 0.4 mA; 72 mGy to 1 m per session; depth rate at 3 cm: 10% 10 7.2 (273) ‡ Very probable dermatitis (>20 Gy). 0.7 (26.60) Up to 3/38 full sessions ‖ Possible scenarios. 20 1.8 (68.4) ‡ Very probable dermatitis (>20 Gy). 0.18 (6.84) Up to 12/38 full sessions ‖ Possible scenarios. 30 0.8 (30.4) ‡ Very probable dermatitis (>20 Gy). 0.08 (3.00) Up to 27/38 full sessions ‖ Possible scenarios. 40 0.45 (17.1) 0.045 (1.75) § Very probable lack of therapeutic efficiency even for a radiosensitive tumor (<2 Gy). No 40 kV: 11-mm spark; 0.3 mA; 54 mGy to 1 m per session; depth rate at 3 cm: 60% 10 5.4 (205) ‡ Very probable dermatitis (>20 Gy). 3.24 (123) Up to 4/38 full sessions ‖ Possible scenarios. 20 1.35 (51.3) ‡ Very probable dermatitis (>20 Gy). 0.81 (30.78) Up to 16/38 full sessions ‖ Possible scenarios. 30 0.6 (22.8) ‖ Possible scenarios. 0.36 (13.68) ‖ Possible scenarios. Up to 36/38 full sessions ‖ Possible scenarios. 40 0.33 (12.54) ‖ Possible scenarios. 0.2 (7.60) ‖ Possible scenarios. No ∗ The treatment was 2 sessions per day for 19 days. † With less than 21 Gy at the skin and more than 2 Gy in 3 cm depth. ‡ Very probable dermatitis (>20 Gy). § Very probable lack of therapeutic efficiency even for a radiosensitive tumor (<2 Gy). ‖ Possible scenarios. Open table in a new tab In Regard to ForayInternational Journal of Radiation Oncology, Biology, PhysicsVol. 97Issue 5PreviewTo the Editor: We were fascinated by Nicolas Foray's account of the life and work of Victor Despeignes (1) and the circumstances surrounding his brief investigation of the therapeutic properties of x-rays. We were puzzled, however, by Professor Foray's estimation of delivered dose (0.36 Gy at 3-cm depth, per 30-minute session), because there was a paucity of data necessary to make such a calculation. Full-Text PDF" @default.
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• W2602623333 date "2017-04-01" @default.
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• W2602623333 title "In Reply to Aronowitz and Grimard" @default.
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• W2602623333 doi "https://doi.org/10.1016/j.ijrobp.2017.01.012" @default.
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