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• W2602663546 abstract "Erythropoietin (Epo) is the main hormone that regulates the production of red blood cells (hematopoiesis), by stimulating their progenitors. Beyond this vital function, several emerging roles have been noted for Epo in other tissues, including neurons, heart, and retina. The skeletal system is also affected by Epo; however, its actions on bone are, as yet, controversial. Here, we review the seemingly contradicting evidence regarding Epo effects on bone remodeling. We also discuss the evidence pointing to a direct vs indirect effect of Epo on the osteoblastic and osteoclastic cell lineages. The current controversy may derive from a context-dependent mode of function of Epo, namely, opposite skeletal actions during bone regeneration and steady-state bone remodeling. Differences in conclusions deriving from the published in vitro studies may thus relate to the different experimental conditions. Taken together, the current state-of-the-art indicates definite Epo effects on bone cells and points to the complexity of the mode of function." @default.
• W2602663546 created "2017-04-07" @default.
• W2602663546 creator A5007164548 @default.
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• W2602663546 date "2017-01-01" @default.
• W2602663546 modified "2023-09-26" @default.
• W2602663546 title "Context-Dependent Skeletal Effects of Erythropoietin" @default.
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• W2602663546 doi "https://doi.org/10.1016/bs.vh.2017.02.003" @default.
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• W2602663546 hasPublicationYear "2017" @default.
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