Matches in SemOpenAlex for { <https://semopenalex.org/work/W2602677378> ?p ?o ?g. }
- W2602677378 endingPage "603" @default.
- W2602677378 startingPage "595" @default.
- W2602677378 abstract "Objectives Antiretroviral therapy (ART) has been associated with unfavourable lipid profile changes and increased risk of cardiovascular disease (CVD). With a growing population on ART in South Africa, there has been concern about the increase in noncommunicable diseases such as CVD. We determined risk factors associated with increased total cholesterol (TC) in a large cohort on ART and describe the clinical management thereof. Methods We conducted an observational cohort study of ART-naïve adults initiating standard first-line ART in a large urban clinic in Johannesburg, South Africa. TC was measured annually for most patients. A proportional hazards regression model was used to determine risk factors associated with incident high TC (≥ 6 mmol/L). Results Significant risk factors included initial regimen non-tenofovir vs. tenofovir [hazard ratio (HR) 1.54; 95% confidence interval (CI) 1.14–2.08], age ≥40 vs. <30 years (HR 3.22; 95% CI 2.07–4.99), body mass index (BMI) ≥ 30 kg/m2 (HR 1.65; 95% CI 1.18–2.31) and BMI 25–29.9 kg/m2 (HR 1.70; 95% CI 1.30–2.23) vs. 18–24.9 kg/m2, and baseline CD4 count < 50 cells/μL (HR 1.55; 95% CI 1.10–2.20) and 50–99 cells/μL (HR 1.40; 95% CI 1.00–1.97) vs. > 200 cells/μL. Two-thirds of patients with high TC were given cholesterol-lowering drugs, after repeat TC measurements about 12 months apart, while 31.8% were likely to have received dietary counselling only. Conclusions Older age, higher BMI, lower CD4 count and a non-tenofovir regimen were risk factors for incident elevated TC. Current guidelines do not indicate regular cholesterol testing at ART clinic visits, which are the main exposure to regular clinical monitoring for most HIV-positive individuals. If regular cholesterol monitoring is conducted, improvements can be made to identify and treat patients sooner." @default.
- W2602677378 created "2017-04-07" @default.
- W2602677378 creator A5001200235 @default.
- W2602677378 creator A5010315274 @default.
- W2602677378 creator A5011983951 @default.
- W2602677378 creator A5043521822 @default.
- W2602677378 creator A5050583060 @default.
- W2602677378 creator A5052776114 @default.
- W2602677378 creator A5058631355 @default.
- W2602677378 creator A5066253506 @default.
- W2602677378 creator A5079771150 @default.
- W2602677378 creator A5091239351 @default.
- W2602677378 date "2017-03-23" @default.
- W2602677378 modified "2023-10-15" @default.
- W2602677378 title "Changes in elevated cholesterol in the era of tenofovir in South Africa: risk factors, clinical management and outcomes" @default.
- W2602677378 cites W1964397909 @default.
- W2602677378 cites W1976829400 @default.
- W2602677378 cites W1980867271 @default.
- W2602677378 cites W1984871995 @default.
- W2602677378 cites W1985667653 @default.
- W2602677378 cites W2013255079 @default.
- W2602677378 cites W2015442730 @default.
- W2602677378 cites W2019118236 @default.
- W2602677378 cites W2025935180 @default.
- W2602677378 cites W2027982480 @default.
- W2602677378 cites W2038756830 @default.
- W2602677378 cites W2040028729 @default.
- W2602677378 cites W2067605835 @default.
- W2602677378 cites W2069749827 @default.
- W2602677378 cites W2082813245 @default.
- W2602677378 cites W2094925527 @default.
- W2602677378 cites W2102537552 @default.
- W2602677378 cites W2120637537 @default.
- W2602677378 cites W2139508877 @default.
- W2602677378 cites W2141741448 @default.
- W2602677378 cites W2159584933 @default.
- W2602677378 cites W2163400856 @default.
- W2602677378 cites W2398957109 @default.
- W2602677378 cites W4296391115 @default.
- W2602677378 doi "https://doi.org/10.1111/hiv.12495" @default.
- W2602677378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28332270" @default.
- W2602677378 hasPublicationYear "2017" @default.
- W2602677378 type Work @default.
- W2602677378 sameAs 2602677378 @default.
- W2602677378 citedByCount "7" @default.
- W2602677378 countsByYear W26026773782018 @default.
- W2602677378 countsByYear W26026773782019 @default.
- W2602677378 countsByYear W26026773782020 @default.
- W2602677378 countsByYear W26026773782021 @default.
- W2602677378 countsByYear W26026773782022 @default.
- W2602677378 crossrefType "journal-article" @default.
- W2602677378 hasAuthorship W2602677378A5001200235 @default.
- W2602677378 hasAuthorship W2602677378A5010315274 @default.
- W2602677378 hasAuthorship W2602677378A5011983951 @default.
- W2602677378 hasAuthorship W2602677378A5043521822 @default.
- W2602677378 hasAuthorship W2602677378A5050583060 @default.
- W2602677378 hasAuthorship W2602677378A5052776114 @default.
- W2602677378 hasAuthorship W2602677378A5058631355 @default.
- W2602677378 hasAuthorship W2602677378A5066253506 @default.
- W2602677378 hasAuthorship W2602677378A5079771150 @default.
- W2602677378 hasAuthorship W2602677378A5091239351 @default.
- W2602677378 hasBestOaLocation W26026773781 @default.
- W2602677378 hasConcept C126322002 @default.
- W2602677378 hasConcept C201903717 @default.
- W2602677378 hasConcept C207103383 @default.
- W2602677378 hasConcept C2780221984 @default.
- W2602677378 hasConcept C2781413609 @default.
- W2602677378 hasConcept C2908647359 @default.
- W2602677378 hasConcept C44249647 @default.
- W2602677378 hasConcept C50382708 @default.
- W2602677378 hasConcept C71924100 @default.
- W2602677378 hasConcept C72563966 @default.
- W2602677378 hasConcept C99454951 @default.
- W2602677378 hasConceptScore W2602677378C126322002 @default.
- W2602677378 hasConceptScore W2602677378C201903717 @default.
- W2602677378 hasConceptScore W2602677378C207103383 @default.
- W2602677378 hasConceptScore W2602677378C2780221984 @default.
- W2602677378 hasConceptScore W2602677378C2781413609 @default.
- W2602677378 hasConceptScore W2602677378C2908647359 @default.
- W2602677378 hasConceptScore W2602677378C44249647 @default.
- W2602677378 hasConceptScore W2602677378C50382708 @default.
- W2602677378 hasConceptScore W2602677378C71924100 @default.
- W2602677378 hasConceptScore W2602677378C72563966 @default.
- W2602677378 hasConceptScore W2602677378C99454951 @default.
- W2602677378 hasFunder F4320306115 @default.
- W2602677378 hasIssue "8" @default.
- W2602677378 hasLocation W26026773781 @default.
- W2602677378 hasLocation W26026773782 @default.
- W2602677378 hasOpenAccess W2602677378 @default.
- W2602677378 hasPrimaryLocation W26026773781 @default.
- W2602677378 hasRelatedWork W1516595110 @default.
- W2602677378 hasRelatedWork W2026094606 @default.
- W2602677378 hasRelatedWork W2071306276 @default.
- W2602677378 hasRelatedWork W2084774262 @default.
- W2602677378 hasRelatedWork W2166728574 @default.
- W2602677378 hasRelatedWork W2490521022 @default.
- W2602677378 hasRelatedWork W2532729589 @default.
- W2602677378 hasRelatedWork W2611840721 @default.