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• W2602691345 abstract "Both anti-PD1/PD-L1 therapy and oncolytic virotherapy have demonstrated promise, yet have exhibited efficacy in only a small fraction of cancer patients. Here we hypothesized that an oncolytic poxvirus would attract T cells into the tumour, and induce PD-L1 expression in cancer and immune cells, leading to more susceptible targets for anti-PD-L1 immunotherapy. Our results demonstrate in colon and ovarian cancer models that an oncolytic vaccinia virus attracts effector T cells and induces PD-L1 expression on both cancer and immune cells in the tumour. The dual therapy reduces PD-L1+ cells and facilitates non-redundant tumour infiltration of effector CD8+, CD4+ T cells, with increased IFN-γ, ICOS, granzyme B and perforin expression. Furthermore, the treatment reduces the virus-induced PD-L1+ DC, MDSC, TAM and Treg, as well as co-inhibitory molecules-double-positive, severely exhausted PD-1+CD8+ T cells, leading to reduced tumour burden and improved survival. This combinatorial therapy may be applicable to a much wider population of cancer patients." @default.
• W2602691345 created "2017-04-07" @default.
• W2602691345 creator A5007616348 @default.
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• W2602691345 date "2017-03-27" @default.
• W2602691345 modified "2023-10-16" @default.
• W2602691345 title "Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy" @default.
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• W2602691345 doi "https://doi.org/10.1038/ncomms14754" @default.
• W2602691345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5378974" @default.
• W2602691345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28345650" @default.
• W2602691345 hasPublicationYear "2017" @default.
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