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- W2602711968 abstract "Uncontrolled proliferation of nerve tissue or neuroma is a painful and prevalent clinical problem. Surgical removal, the main treatment option, is largely ineffective as neuromas often grow back. Available models show a high degree of variability and are often so traumatic they result in autonomy. Here we present a sural nerve ligation model of neuroma in the mouse, which produces no motor deficits or autonomy. We observed that a simple ligation of the sural branch of the sciatic nerve results in the appearance of a large neural mass reminiscent of a neuroma. Indeed, this mass expresses high amounts of the human neuroma marker semaphorin 3A, Sema3a, and is associated with strong behavioral changes in allodynia in female mice. To better understand neuroma formation we determined which sensory neuron subtypes contribute to the sural nerve using retrograde Fluoro-Gold (FG) labeling. We observed FG+ neuronal bodies in the L3, 4 and 5 dorsal root ganglia. Follow-up immunostaining revealed that 20-40% of these neurons are positive for neurofilament heavy, a marker of large diameter general sensory neurons. The remaining 60-80% of FG+ neurons were positive for isolectin B4 typical of small diameter nonpeptidergic nociceptive neurons. Continuing studies will investigate the effect of sural nerve ligation in male mice and will allow us to dissect the basic biology of neuroma." @default.
- W2602711968 created "2017-04-07" @default.
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- W2602711968 date "2017-04-01" @default.
- W2602711968 modified "2023-09-23" @default.
- W2602711968 title "(151) A novel murine neuroma model: sural ligation results in neuroma formation and the up-regulation of Sema3A" @default.
- W2602711968 doi "https://doi.org/10.1016/j.jpain.2017.02.057" @default.
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