FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2602743668> ?p ?o ?g. }

• W2602743668 endingPage "1653" @default.
• W2602743668 startingPage "1640" @default.
• W2602743668 abstract "Coronary artery disease (CAD) is the leading cause of death worldwide. GWAS have identified >50 genomic loci for CAD, including ADTRP and MIA3/TANGO1. However, it is important to determine whether the GWAS genes form a molecular network. In this study, we have uncovered a novel molecular network between ADTRP and MIA3/TANGO1 for the pathogenesis of CAD. We showed that knockdown of ADTRP expression markedly down-regulated expression of MIA3/TANGO1. Mechanistically, ADTRP positively regulates expression of PIK3R3 encoding the regulatory subunit 3 of PI3K, which leads to activation of AKT, resulting in up-regulation of MIA3/TANGO1. Both ADTRP and MIA3/TANGO1 are involved in endothelial cell (EC) functions relevant to atherosclerosis. Knockdown of ADTRP expression by siRNA promoted oxidized-LDL-mediated monocyte adhesion to ECs and transendothelial migration of monocytes, inhibited EC proliferation and migration, and increased apoptosis, which was reversed by expression of constitutively active AKT1 and MIA3/TANGO1 overexpression, while the over-expression of ADTRP in ECs blunted these processes. Knockdown of MIA3/TANGO1 expression also promoted monocyte adhesion to ECs and transendothelial migration of monocytes, and vice versa for overexpression of MIA3/TANGO1. We found that ADTRP negatively regulates the levels of collagen VII and ApoB in HepG2 and endothelial cells, which are downstream regulatory targets of MIA3/TANGOI. In conclusion, we have uncovered a novel molecular signaling pathway for the pathogenesis of CAD, which involves a novel gene-gene regulatory network. We show that ADTRP positively regulates PIK3R3 expression, which leads to activation of AKT and up-regulation of MIA3/TANGO1, thereby regulating endothelial cell functions directly relevant to atherosclerosis." @default.
• W2602743668 created "2017-04-07" @default.
• W2602743668 creator A5010515168 @default.
• W2602743668 creator A5010817329 @default.
• W2602743668 creator A5013312806 @default.
• W2602743668 creator A5018568072 @default.
• W2602743668 creator A5018955133 @default.
• W2602743668 creator A5026740048 @default.
• W2602743668 creator A5030800777 @default.
• W2602743668 creator A5038836690 @default.
• W2602743668 creator A5067597205 @default.
• W2602743668 creator A5090258099 @default.
• W2602743668 date "2017-06-01" @default.
• W2602743668 modified "2023-10-15" @default.
• W2602743668 title "Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease" @default.
• W2602743668 cites W1658308648 @default.
• W2602743668 cites W1884981594 @default.
• W2602743668 cites W1966136633 @default.
• W2602743668 cites W1994688467 @default.
• W2602743668 cites W2006852789 @default.
• W2602743668 cites W2008921252 @default.
• W2602743668 cites W2016087472 @default.
• W2602743668 cites W2020229308 @default.
• W2602743668 cites W2026517602 @default.
• W2602743668 cites W2041530076 @default.
• W2602743668 cites W2044079910 @default.
• W2602743668 cites W2052269433 @default.
• W2602743668 cites W2054273868 @default.
• W2602743668 cites W2066963386 @default.
• W2602743668 cites W2068896961 @default.
• W2602743668 cites W2111744537 @default.
• W2602743668 cites W2135205767 @default.
• W2602743668 cites W2141150401 @default.
• W2602743668 cites W2141501509 @default.
• W2602743668 cites W2150302710 @default.
• W2602743668 cites W2155598980 @default.
• W2602743668 cites W2165821316 @default.
• W2602743668 cites W2206905095 @default.
• W2602743668 cites W2257910699 @default.
• W2602743668 cites W2294120549 @default.
• W2602743668 cites W2296538922 @default.
• W2602743668 cites W2344228184 @default.
• W2602743668 cites W2406264304 @default.
• W2602743668 doi "https://doi.org/10.1016/j.bbadis.2017.03.010" @default.
• W2602743668 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5616168" @default.
• W2602743668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28341552" @default.
• W2602743668 hasPublicationYear "2017" @default.
• W2602743668 type Work @default.
• W2602743668 sameAs 2602743668 @default.
• W2602743668 citedByCount "28" @default.
• W2602743668 countsByYear W26027436682017 @default.
• W2602743668 countsByYear W26027436682018 @default.
• W2602743668 countsByYear W26027436682019 @default.
• W2602743668 countsByYear W26027436682020 @default.
• W2602743668 countsByYear W26027436682021 @default.
• W2602743668 countsByYear W26027436682022 @default.
• W2602743668 countsByYear W26027436682023 @default.
• W2602743668 crossrefType "journal-article" @default.
• W2602743668 hasAuthorship W2602743668A5010515168 @default.
• W2602743668 hasAuthorship W2602743668A5010817329 @default.
• W2602743668 hasAuthorship W2602743668A5013312806 @default.
• W2602743668 hasAuthorship W2602743668A5018568072 @default.
• W2602743668 hasAuthorship W2602743668A5018955133 @default.
• W2602743668 hasAuthorship W2602743668A5026740048 @default.
• W2602743668 hasAuthorship W2602743668A5030800777 @default.
• W2602743668 hasAuthorship W2602743668A5038836690 @default.
• W2602743668 hasAuthorship W2602743668A5067597205 @default.
• W2602743668 hasAuthorship W2602743668A5090258099 @default.
• W2602743668 hasBestOaLocation W26027436681 @default.
• W2602743668 hasConcept C104317684 @default.
• W2602743668 hasConcept C106208931 @default.
• W2602743668 hasConcept C135763542 @default.
• W2602743668 hasConcept C153209595 @default.
• W2602743668 hasConcept C154137905 @default.
• W2602743668 hasConcept C173396325 @default.
• W2602743668 hasConcept C203014093 @default.
• W2602743668 hasConcept C2780942790 @default.
• W2602743668 hasConcept C502942594 @default.
• W2602743668 hasConcept C54355233 @default.
• W2602743668 hasConcept C62478195 @default.
• W2602743668 hasConcept C75217442 @default.
• W2602743668 hasConcept C86554907 @default.
• W2602743668 hasConcept C86803240 @default.
• W2602743668 hasConcept C95444343 @default.
• W2602743668 hasConceptScore W2602743668C104317684 @default.
• W2602743668 hasConceptScore W2602743668C106208931 @default.
• W2602743668 hasConceptScore W2602743668C135763542 @default.
• W2602743668 hasConceptScore W2602743668C153209595 @default.
• W2602743668 hasConceptScore W2602743668C154137905 @default.
• W2602743668 hasConceptScore W2602743668C173396325 @default.
• W2602743668 hasConceptScore W2602743668C203014093 @default.
• W2602743668 hasConceptScore W2602743668C2780942790 @default.
• W2602743668 hasConceptScore W2602743668C502942594 @default.
• W2602743668 hasConceptScore W2602743668C54355233 @default.
• W2602743668 hasConceptScore W2602743668C62478195 @default.
• W2602743668 hasConceptScore W2602743668C75217442 @default.
• W2602743668 hasConceptScore W2602743668C86554907 @default.
• W2602743668 hasConceptScore W2602743668C86803240 @default.

• next