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• W2602840180 abstract "The obscurin family of polypeptides is essential for normal striated muscle function and contributes to the pathogenesis of fatal diseases, including cardiomyopathies and cancers. The single mammalian obscurin gene, OBSCN, gives rise to giant (∼800 kDa) and smaller (∼40–500 kDa) proteins that are composed of tandem adhesion and signaling motifs. Mammalian obscurin proteins are expressed in a variety of cell types, including striated muscles, and localize to distinct subcellular compartments where they contribute to diverse cellular processes. Obscurin homologs in Caenorhabditis elegans and Drosophila possess a similar domain architecture and are also expressed in striated muscles. The long sought after question, “what does obscurin do?” is complex and cannot be addressed without taking into consideration the subcellular distribution of these proteins and local isoform concentration. Herein, we present an overview of the functions of obscurins and begin to define the intricate relationship between their subcellular distributions and functions in striated muscles." @default.
• W2602840180 created "2017-04-07" @default.
• W2602840180 creator A5031807808 @default.
• W2602840180 creator A5034583338 @default.
• W2602840180 creator A5050623823 @default.
• W2602840180 date "2017-03-29" @default.
• W2602840180 modified "2023-09-23" @default.
• W2602840180 title "Obscure functions: the location–function relationship of obscurins" @default.
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• W2602840180 doi "https://doi.org/10.1007/s12551-017-0254-x" @default.
• W2602840180 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5498325" @default.
• W2602840180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28510116" @default.
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