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• W2602895543 abstract "Paradoxical sleep is closely associated with depression, and brain monoamine oxidase A (MAOA) plays an important role in depression. However, the precise relationship between sleep and depression and the role of MAOA in this process remains unknown. Therefore, we established a paradoxical sleep deprivation model using the “multiple small platforms over water” protocol. Mice deprived of paradoxical sleep for 3 days showed no depressive-like behaviors; however, mice deprived of paradoxical sleep deprivation for 5 days (P5d) showed decreased locomotive activity in the first 3 days after P5d. Additionally, the P5d mice showed depressive-like behaviors one week after P5d, with a longer immobility time and a decreased sucrose preference rate. In addition, the levels of the MAOA protein and mRNA in the amygdala and hippocampus significantly increased. Furthermore, the immobility time and sucrose preference rate of P5d mice recovered when the mice were injected with phenelzine. The P5d mice displayed depressive-like behaviors, which were likely modulated by the MAOA levels in the amygdala and hippocampus." @default.
• W2602895543 created "2017-04-07" @default.
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• W2602895543 date "2017-06-01" @default.
• W2602895543 modified "2023-09-24" @default.
• W2602895543 title "Paradoxical sleep deprivation modulates depressive-like behaviors by regulating the MAOA levels in the amygdala and hippocampus" @default.
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• W2602895543 doi "https://doi.org/10.1016/j.brainres.2017.03.022" @default.
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