Matches in SemOpenAlex for { <https://semopenalex.org/work/W2602912164> ?p ?o ?g. }
- W2602912164 endingPage "101042831769454" @default.
- W2602912164 startingPage "101042831769454" @default.
- W2602912164 abstract "Autotaxin, an ecto-lysophospholipase D encoded by the human ENNP2 gene, is expressed in multiple tissues, and participates in numerous critical physiologic and pathologic processes including inflammation, pain, obesity, embryo development, and cancer via the generation of the bioactive lipid lysophosphatidate. Overwhelming evidences indicate that the autotaxin/lysophosphatidate signaling axis serves key roles in the numerous processes central to tumorigenesis and progression, including proliferation, survival, migration, invasion, metastasis, cancer stem cell, tumor microenvironment, and treatment resistance by interacting with a series of at least six G-protein-coupled receptors (LPAR1–6). This review provides an overview of the autotaxin/lysophosphatidate axis and collates current knowledge regarding its specific role in pancreatic cancer. With a deeper understanding of the critical role of the autotaxin/lysophosphatidate axis in pancreatic cancer, targeting autotaxin or lysophosphatidate receptor may be a potential and promising strategy for cancer therapy." @default.
- W2602912164 created "2017-04-07" @default.
- W2602912164 creator A5012670662 @default.
- W2602912164 creator A5044145840 @default.
- W2602912164 creator A5045897433 @default.
- W2602912164 creator A5047704890 @default.
- W2602912164 date "2017-03-01" @default.
- W2602912164 modified "2023-10-16" @default.
- W2602912164 title "The critical role and potential target of the autotaxin/lysophosphatidate axis in pancreatic cancer" @default.
- W2602912164 cites W1480379639 @default.
- W2602912164 cites W1482279273 @default.
- W2602912164 cites W1549006420 @default.
- W2602912164 cites W1565276921 @default.
- W2602912164 cites W1568436538 @default.
- W2602912164 cites W1577193899 @default.
- W2602912164 cites W1671871957 @default.
- W2602912164 cites W1801090207 @default.
- W2602912164 cites W1900808926 @default.
- W2602912164 cites W1905844814 @default.
- W2602912164 cites W1906409273 @default.
- W2602912164 cites W1958040920 @default.
- W2602912164 cites W1963865721 @default.
- W2602912164 cites W1963973724 @default.
- W2602912164 cites W1972426718 @default.
- W2602912164 cites W1973398707 @default.
- W2602912164 cites W1974170084 @default.
- W2602912164 cites W1974249706 @default.
- W2602912164 cites W1977452665 @default.
- W2602912164 cites W1977733200 @default.
- W2602912164 cites W1978992544 @default.
- W2602912164 cites W1979571079 @default.
- W2602912164 cites W1979710105 @default.
- W2602912164 cites W1981681375 @default.
- W2602912164 cites W1982426576 @default.
- W2602912164 cites W1984888890 @default.
- W2602912164 cites W1985551319 @default.
- W2602912164 cites W1985655279 @default.
- W2602912164 cites W1987520856 @default.
- W2602912164 cites W1990390822 @default.
- W2602912164 cites W1992203600 @default.
- W2602912164 cites W1999536759 @default.
- W2602912164 cites W1999599951 @default.
- W2602912164 cites W2000142355 @default.
- W2602912164 cites W2003992176 @default.
- W2602912164 cites W2004161103 @default.
- W2602912164 cites W2006993784 @default.
- W2602912164 cites W2007913764 @default.
- W2602912164 cites W2009901983 @default.
- W2602912164 cites W2010110193 @default.
- W2602912164 cites W2012959081 @default.
- W2602912164 cites W2013109407 @default.
- W2602912164 cites W2014103703 @default.
- W2602912164 cites W2019011349 @default.
- W2602912164 cites W2019122456 @default.
- W2602912164 cites W2021606806 @default.
- W2602912164 cites W2024375126 @default.
- W2602912164 cites W2027924835 @default.
- W2602912164 cites W2029192296 @default.
- W2602912164 cites W2036011686 @default.
- W2602912164 cites W2036015482 @default.
- W2602912164 cites W2037684531 @default.
- W2602912164 cites W2039346157 @default.
- W2602912164 cites W2039826543 @default.
- W2602912164 cites W2043024075 @default.
- W2602912164 cites W2046351465 @default.
- W2602912164 cites W2048765473 @default.
- W2602912164 cites W2053431943 @default.
- W2602912164 cites W2054414187 @default.
- W2602912164 cites W2062900990 @default.
- W2602912164 cites W2064686830 @default.
- W2602912164 cites W2071478988 @default.
- W2602912164 cites W2072303589 @default.
- W2602912164 cites W2072316009 @default.
- W2602912164 cites W2074969762 @default.
- W2602912164 cites W2078511357 @default.
- W2602912164 cites W2079878922 @default.
- W2602912164 cites W2081779198 @default.
- W2602912164 cites W2082424812 @default.
- W2602912164 cites W2086221798 @default.
- W2602912164 cites W2090394402 @default.
- W2602912164 cites W2092846037 @default.
- W2602912164 cites W2094210837 @default.
- W2602912164 cites W2099380050 @default.
- W2602912164 cites W2107007984 @default.
- W2602912164 cites W2108812575 @default.
- W2602912164 cites W2109710025 @default.
- W2602912164 cites W2111598714 @default.
- W2602912164 cites W2113001776 @default.
- W2602912164 cites W2114581301 @default.
- W2602912164 cites W2115833242 @default.
- W2602912164 cites W2119097555 @default.
- W2602912164 cites W2121733433 @default.
- W2602912164 cites W2122781473 @default.
- W2602912164 cites W2124440700 @default.
- W2602912164 cites W2124900560 @default.
- W2602912164 cites W2132260833 @default.
- W2602912164 cites W2134234357 @default.
- W2602912164 cites W2135935628 @default.