Matches in SemOpenAlex for { <https://semopenalex.org/work/W2602970936> ?p ?o ?g. }
- W2602970936 endingPage "66" @default.
- W2602970936 startingPage "60" @default.
- W2602970936 abstract "Esophageal cancers (EC) are highly aggressive tumors, commonly presented in a locally advanced stage with a poor prognosis and survival. Up to 50% of the patients are eligible for treatment with curative intent and receive the standard treatment with neoadjuvant chemoradiotherapy (nCRT) and surgery. Currently, pathologic complete response to nCRT is 20-30%, with a partial or no response in about 50% and 20%, respectively. EC recurrences occur frequently even after successful anti-cancer treatment, suggesting high aggressiveness with increased metastatic potential. A tumor sub-population of so-called cancer stem cells (CSCs), is known to display a high metastatic potential and resistance to conventional anti-cancer therapy, hereby being responsible for the unbeneficial clinical features. In this review, a concise overview will be given of the current literature on esophageal CSCs and related metastases. Esophageal CSC markers will be discussed followed by the pathways that initiate and sustain these cells. In addition, the cellular processes, epithelial-mesenchymal transition (EMT), hypoxia and autophagy, known to contribute to cancer stemness and metastasis will be explained. Finally, potential options for treatment also related to cancer genome atlas (TCGA) data on EC will be discussed." @default.
- W2602970936 created "2017-04-07" @default.
- W2602970936 creator A5026386651 @default.
- W2602970936 creator A5053002026 @default.
- W2602970936 creator A5078429982 @default.
- W2602970936 date "2017-06-01" @default.
- W2602970936 modified "2023-09-30" @default.
- W2602970936 title "Cancer stem cells with increased metastatic potential as a therapeutic target for esophageal cancer" @default.
- W2602970936 cites W1483167997 @default.
- W2602970936 cites W1511178527 @default.
- W2602970936 cites W1529084294 @default.
- W2602970936 cites W1529130393 @default.
- W2602970936 cites W1550435576 @default.
- W2602970936 cites W1574188817 @default.
- W2602970936 cites W1594426752 @default.
- W2602970936 cites W1892707315 @default.
- W2602970936 cites W1965568759 @default.
- W2602970936 cites W1969585894 @default.
- W2602970936 cites W1972565566 @default.
- W2602970936 cites W1978301900 @default.
- W2602970936 cites W1980714336 @default.
- W2602970936 cites W1985405863 @default.
- W2602970936 cites W1989313612 @default.
- W2602970936 cites W1990361620 @default.
- W2602970936 cites W1992429870 @default.
- W2602970936 cites W1993256844 @default.
- W2602970936 cites W1993643473 @default.
- W2602970936 cites W2002513358 @default.
- W2602970936 cites W2004935845 @default.
- W2602970936 cites W2006174435 @default.
- W2602970936 cites W2009485201 @default.
- W2602970936 cites W2009886857 @default.
- W2602970936 cites W2015507381 @default.
- W2602970936 cites W2015717966 @default.
- W2602970936 cites W2016496420 @default.
- W2602970936 cites W2018580411 @default.
- W2602970936 cites W2019216935 @default.
- W2602970936 cites W2020534880 @default.
- W2602970936 cites W2023061736 @default.
- W2602970936 cites W2024876545 @default.
- W2602970936 cites W2024903578 @default.
- W2602970936 cites W2025945212 @default.
- W2602970936 cites W2033726327 @default.
- W2602970936 cites W2035341810 @default.
- W2602970936 cites W2061226390 @default.
- W2602970936 cites W2062959194 @default.
- W2602970936 cites W2072212990 @default.
- W2602970936 cites W2073159872 @default.
- W2602970936 cites W2073383043 @default.
- W2602970936 cites W2079417712 @default.
- W2602970936 cites W2080812486 @default.
- W2602970936 cites W2080977583 @default.
- W2602970936 cites W2082344079 @default.
- W2602970936 cites W2082558506 @default.
- W2602970936 cites W2084251083 @default.
- W2602970936 cites W2085255144 @default.
- W2602970936 cites W2087962206 @default.
- W2602970936 cites W2090982381 @default.
- W2602970936 cites W2092019540 @default.
- W2602970936 cites W2094865793 @default.
- W2602970936 cites W2095785781 @default.
- W2602970936 cites W2098903674 @default.
- W2602970936 cites W2103512687 @default.
- W2602970936 cites W2106936371 @default.
- W2602970936 cites W2113899464 @default.
- W2602970936 cites W2116069291 @default.
- W2602970936 cites W2116504531 @default.
- W2602970936 cites W2119907371 @default.
- W2602970936 cites W2127107445 @default.
- W2602970936 cites W2128340087 @default.
- W2602970936 cites W2135372007 @default.
- W2602970936 cites W2136922347 @default.
- W2602970936 cites W2139164858 @default.
- W2602970936 cites W2143112776 @default.
- W2602970936 cites W2151293992 @default.
- W2602970936 cites W2154444715 @default.
- W2602970936 cites W2154788827 @default.
- W2602970936 cites W2154857845 @default.
- W2602970936 cites W2157751472 @default.
- W2602970936 cites W2160004726 @default.
- W2602970936 cites W2165254414 @default.
- W2602970936 cites W2170071788 @default.
- W2602970936 cites W2170770040 @default.
- W2602970936 cites W2177462105 @default.
- W2602970936 cites W2214652470 @default.
- W2602970936 cites W2241111255 @default.
- W2602970936 cites W2265008190 @default.
- W2602970936 cites W2297831674 @default.
- W2602970936 cites W2342087103 @default.
- W2602970936 cites W2343950992 @default.
- W2602970936 cites W2405960299 @default.
- W2602970936 cites W2425010760 @default.
- W2602970936 cites W2465250101 @default.
- W2602970936 cites W2520133312 @default.
- W2602970936 cites W2523976396 @default.
- W2602970936 cites W2526505865 @default.
- W2602970936 cites W2560156174 @default.
- W2602970936 cites W2570401594 @default.