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- W2602984299 abstract "Dementia encapsulates a set of symptoms that include loss of mental abilities such as memory, problem solving or language, and reduces a person's ability to perform daily activities. Alzheimer's disease is the most common form of dementia, however dementia can also occur in other neurological disorders such as Huntington's disease (HD). Many studies have demonstrated that loss of neuronal cell function manifests pre-symptomatically and thus is a relevant therapeutic target to alleviate symptoms. Synaptopathy, the physiological dysfunction of synapses, is now being approached as the target for many neurological and psychiatric disorders, including HD. HD is an autosomal dominant and progressive degenerative disorder, with clinical manifestations that encompass movement, cognition, mood and behaviour. HD is one of the most common tandem repeat disorders and is caused by a trinucleotide (CAG) repeat expansion, encoding an extended polyglutamine tract in the huntingtin protein. Animal models as well as human studies have provided detailed, although not exhaustive, evidence of synaptic dysfunction in HD. In this review, we discuss the neuropathology of HD and how the changes in synaptic signalling in the diseased brain lead to its symptoms, which include dementia. Here, we review and discuss the mechanisms by which the 'molecular orchestras' and their 'synaptic symphonies' are disrupted in neurodegeneration and dementia, focusing on HD as a model disease. We also explore the therapeutic strategies currently in pre-clinical and clinical testing that are targeted towards improving synaptic function in HD." @default.
- W2602984299 created "2017-04-07" @default.
- W2602984299 creator A5052976583 @default.
- W2602984299 creator A5071943766 @default.
- W2602984299 date "2017-06-01" @default.
- W2602984299 modified "2023-10-02" @default.
- W2602984299 title "Synaptopathic mechanisms of neurodegeneration and dementia: Insights from Huntington’s disease" @default.
- W2602984299 cites W1138804048 @default.
- W2602984299 cites W1146102393 @default.
- W2602984299 cites W1476192620 @default.
- W2602984299 cites W1487630095 @default.
- W2602984299 cites W1488008685 @default.
- W2602984299 cites W1490649113 @default.
- W2602984299 cites W1496088120 @default.
- W2602984299 cites W1506351306 @default.
- W2602984299 cites W1515218878 @default.
- W2602984299 cites W1519847602 @default.
- W2602984299 cites W1527831788 @default.
- W2602984299 cites W1534602007 @default.
- W2602984299 cites W1535134926 @default.
- W2602984299 cites W1543655975 @default.
- W2602984299 cites W1552525306 @default.
- W2602984299 cites W1570695002 @default.
- W2602984299 cites W1570714205 @default.
- W2602984299 cites W1577751913 @default.
- W2602984299 cites W1579287598 @default.
- W2602984299 cites W1579877956 @default.
- W2602984299 cites W1579975555 @default.
- W2602984299 cites W1588261022 @default.
- W2602984299 cites W1596467522 @default.
- W2602984299 cites W1634993844 @default.
- W2602984299 cites W1639255528 @default.
- W2602984299 cites W1651987642 @default.
- W2602984299 cites W1653383134 @default.
- W2602984299 cites W1670130194 @default.
- W2602984299 cites W1686648970 @default.
- W2602984299 cites W1771616586 @default.
- W2602984299 cites W1780394705 @default.
- W2602984299 cites W1849525423 @default.
- W2602984299 cites W1863572237 @default.
- W2602984299 cites W1879737409 @default.
- W2602984299 cites W1889572575 @default.
- W2602984299 cites W1905860502 @default.
- W2602984299 cites W1915062990 @default.
- W2602984299 cites W1925196301 @default.
- W2602984299 cites W1925492557 @default.
- W2602984299 cites W1936340739 @default.
- W2602984299 cites W1957958801 @default.
- W2602984299 cites W1963552002 @default.
- W2602984299 cites W1964752963 @default.
- W2602984299 cites W1965044068 @default.
- W2602984299 cites W1965247936 @default.
- W2602984299 cites W1965271417 @default.
- W2602984299 cites W1965280907 @default.
- W2602984299 cites W1965492289 @default.
- W2602984299 cites W1965797477 @default.
- W2602984299 cites W1966798058 @default.
- W2602984299 cites W1967075253 @default.
- W2602984299 cites W1967232661 @default.
- W2602984299 cites W1968369841 @default.
- W2602984299 cites W1968746842 @default.
- W2602984299 cites W1969349734 @default.
- W2602984299 cites W1969634414 @default.
- W2602984299 cites W1970235440 @default.
- W2602984299 cites W1970587966 @default.
- W2602984299 cites W1970715987 @default.
- W2602984299 cites W1970733446 @default.
- W2602984299 cites W1971263143 @default.
- W2602984299 cites W1972251644 @default.
- W2602984299 cites W1972262414 @default.
- W2602984299 cites W1972735052 @default.
- W2602984299 cites W1972853510 @default.
- W2602984299 cites W1973074412 @default.
- W2602984299 cites W1973319761 @default.
- W2602984299 cites W1973433476 @default.
- W2602984299 cites W1973765221 @default.
- W2602984299 cites W1973827313 @default.
- W2602984299 cites W1974359993 @default.
- W2602984299 cites W1974486824 @default.
- W2602984299 cites W1974578944 @default.
- W2602984299 cites W1974931223 @default.
- W2602984299 cites W1975086853 @default.
- W2602984299 cites W1975432299 @default.
- W2602984299 cites W1975657842 @default.
- W2602984299 cites W1975823509 @default.
- W2602984299 cites W1975865225 @default.
- W2602984299 cites W1977569817 @default.
- W2602984299 cites W1977801441 @default.
- W2602984299 cites W1977860760 @default.
- W2602984299 cites W1978104052 @default.
- W2602984299 cites W1978723069 @default.
- W2602984299 cites W1978849123 @default.
- W2602984299 cites W1978982532 @default.
- W2602984299 cites W1979305117 @default.
- W2602984299 cites W1979333165 @default.
- W2602984299 cites W1979532884 @default.
- W2602984299 cites W1979720525 @default.
- W2602984299 cites W1979793911 @default.