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- W2603012404 abstract "Abstract Reduction of mitochondrial complex I activity is one of the major hypotheses for dopaminergic neuron death in Parkinson’s disease. However, reduction of complex I activity in all cells or selectively in dopaminergic neurons via conditional deletion of the Ndufs4 gene, a subunit of the mitochondrial complex I, does not cause dopaminergic neuron death or motor impairment. Here, we investigated the effect of reduced complex I activity on non-motor symptoms associated with Parkinson’s disease using conditional knockout (cKO) mice in which Ndufs4 was selectively deleted in dopaminergic neurons ( Ndufs4 cKO). This conditional deletion of Ndufs4, which reduces complex I activity in dopamine neurons, did not cause a significant loss of dopaminergic neurons in substantia nigra pars compacta (SNpc), and there was no loss of dopaminergic neurites in striatum or amygdala. However, Ndufs4 cKO mice had a reduced amount of dopamine in the brain compared to control mice. Furthermore, even though motor behavior were not affected, Ndufs4 cKO mice showed non-motor symptoms experienced by many Parkinson’s disease patients including impaired cognitive function and increased anxiety-like behavior. These data suggest that mitochondrial complex I dysfunction in dopaminergic neurons promotes non-motor symptoms of Parkinson’s disease and reduces dopamine content in the absence of dopamine neuron loss." @default.
- W2603012404 created "2017-04-07" @default.
- W2603012404 creator A5022276825 @default.
- W2603012404 creator A5043837169 @default.
- W2603012404 creator A5050325620 @default.
- W2603012404 creator A5055765486 @default.
- W2603012404 creator A5077956559 @default.
- W2603012404 creator A5087297491 @default.
- W2603012404 date "2017-03-22" @default.
- W2603012404 modified "2023-10-18" @default.
- W2603012404 title "Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson’s disease-like non-motor symptoms without loss of dopamine neurons" @default.
- W2603012404 cites W1504584187 @default.
- W2603012404 cites W1558253339 @default.
- W2603012404 cites W1567738273 @default.
- W2603012404 cites W1764909674 @default.
- W2603012404 cites W1774334900 @default.
- W2603012404 cites W1824655084 @default.
- W2603012404 cites W1868297237 @default.
- W2603012404 cites W1889609763 @default.
- W2603012404 cites W1951695397 @default.
- W2603012404 cites W1964102312 @default.
- W2603012404 cites W1964642241 @default.
- W2603012404 cites W1967659552 @default.
- W2603012404 cites W1967872727 @default.
- W2603012404 cites W1968682241 @default.
- W2603012404 cites W1969800514 @default.
- W2603012404 cites W1970610265 @default.
- W2603012404 cites W1971389338 @default.
- W2603012404 cites W1973392168 @default.
- W2603012404 cites W1974904670 @default.
- W2603012404 cites W1976923181 @default.
- W2603012404 cites W1981631533 @default.
- W2603012404 cites W1983682905 @default.
- W2603012404 cites W1985917760 @default.
- W2603012404 cites W1988565273 @default.
- W2603012404 cites W1989085266 @default.
- W2603012404 cites W1990635133 @default.
- W2603012404 cites W1992633971 @default.
- W2603012404 cites W1994822153 @default.
- W2603012404 cites W1996348906 @default.
- W2603012404 cites W1996793660 @default.
- W2603012404 cites W1996982207 @default.
- W2603012404 cites W1998903131 @default.
- W2603012404 cites W2001799565 @default.
- W2603012404 cites W2004123088 @default.
- W2603012404 cites W2009503896 @default.
- W2603012404 cites W2013257781 @default.
- W2603012404 cites W2017923539 @default.
- W2603012404 cites W2018718529 @default.
- W2603012404 cites W2022425735 @default.
- W2603012404 cites W2022745281 @default.
- W2603012404 cites W2022834361 @default.
- W2603012404 cites W2023192233 @default.
- W2603012404 cites W2023504042 @default.
- W2603012404 cites W2026648000 @default.
- W2603012404 cites W2026674234 @default.
- W2603012404 cites W2038135846 @default.
- W2603012404 cites W2041561931 @default.
- W2603012404 cites W2047509793 @default.
- W2603012404 cites W2051694207 @default.
- W2603012404 cites W2053139891 @default.
- W2603012404 cites W2057079766 @default.
- W2603012404 cites W2068462701 @default.
- W2603012404 cites W2069951554 @default.
- W2603012404 cites W2070353528 @default.
- W2603012404 cites W2070758175 @default.
- W2603012404 cites W2073351779 @default.
- W2603012404 cites W2073449985 @default.
- W2603012404 cites W2074833985 @default.
- W2603012404 cites W2076229820 @default.
- W2603012404 cites W2079749027 @default.
- W2603012404 cites W2082265886 @default.
- W2603012404 cites W2087957743 @default.
- W2603012404 cites W2091164797 @default.
- W2603012404 cites W2092462980 @default.
- W2603012404 cites W2092871687 @default.
- W2603012404 cites W2094734516 @default.
- W2603012404 cites W2097028758 @default.
- W2603012404 cites W2098164623 @default.
- W2603012404 cites W2099621231 @default.
- W2603012404 cites W2100967174 @default.
- W2603012404 cites W2101090693 @default.
- W2603012404 cites W2106228309 @default.
- W2603012404 cites W2111682630 @default.
- W2603012404 cites W2112110541 @default.
- W2603012404 cites W2112777355 @default.
- W2603012404 cites W2124002387 @default.
- W2603012404 cites W2126516300 @default.
- W2603012404 cites W2135335338 @default.
- W2603012404 cites W2136372119 @default.
- W2603012404 cites W2139700140 @default.
- W2603012404 cites W2142477765 @default.
- W2603012404 cites W2143959688 @default.
- W2603012404 cites W2152860360 @default.
- W2603012404 cites W2156411508 @default.
- W2603012404 cites W2163543612 @default.
- W2603012404 cites W2165382565 @default.
- W2603012404 cites W2165935299 @default.
- W2603012404 cites W2182045965 @default.
- W2603012404 cites W2293877091 @default.