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- W2603204608 abstract "Aberrant signal transduction downstream of the Ras GTPase has a well-established role in tumorigenesis. Mutations that result in hyperactivation of Ras are responsible for a third of all human cancers. Hence, small molecule inhibitors of the Ras signal transduction cascade have been under intense focus as potential cancer treatments. In both invertebrate and mammalian models, emerging evidence has also implicated components of the Ras signaling pathway in aging and metabolic regulation. Here, I review the current evidence for Ras signaling in these newly discovered roles highlighting the interactions between the Ras pathway and other longevity assurance mechanisms. Defining the role of Ras signaling in maintaining age-related health may have important implications for the development of interventions that could not only increase lifespan but also delay the onset and/or progression of age-related functional decline." @default.
- W2603204608 created "2017-04-07" @default.
- W2603204608 creator A5040077574 @default.
- W2603204608 date "2017-12-07" @default.
- W2603204608 modified "2023-10-10" @default.
- W2603204608 title "Ras signaling in aging and metabolic regulation" @default.
- W2603204608 cites W105081038 @default.
- W2603204608 cites W1522402713 @default.
- W2603204608 cites W1541192889 @default.
- W2603204608 cites W1542093096 @default.
- W2603204608 cites W1546913027 @default.
- W2603204608 cites W1548842533 @default.
- W2603204608 cites W1572421661 @default.
- W2603204608 cites W1891854262 @default.
- W2603204608 cites W1909120931 @default.
- W2603204608 cites W1965972240 @default.
- W2603204608 cites W1966609929 @default.
- W2603204608 cites W1968905630 @default.
- W2603204608 cites W1971727526 @default.
- W2603204608 cites W1972186273 @default.
- W2603204608 cites W1973246057 @default.
- W2603204608 cites W1973372369 @default.
- W2603204608 cites W1976995422 @default.
- W2603204608 cites W1979793654 @default.
- W2603204608 cites W1984118305 @default.
- W2603204608 cites W1987738803 @default.
- W2603204608 cites W1989759127 @default.
- W2603204608 cites W1995040522 @default.
- W2603204608 cites W1995999613 @default.
- W2603204608 cites W1998203489 @default.
- W2603204608 cites W1999108035 @default.
- W2603204608 cites W2002622198 @default.
- W2603204608 cites W2007740186 @default.
- W2603204608 cites W2013022444 @default.
- W2603204608 cites W2015010022 @default.
- W2603204608 cites W2016021819 @default.
- W2603204608 cites W2017353764 @default.
- W2603204608 cites W2019041167 @default.
- W2603204608 cites W2019755675 @default.
- W2603204608 cites W2020590763 @default.
- W2603204608 cites W2024123645 @default.
- W2603204608 cites W2024369771 @default.
- W2603204608 cites W2025872894 @default.
- W2603204608 cites W2026522246 @default.
- W2603204608 cites W2027272551 @default.
- W2603204608 cites W2028415754 @default.
- W2603204608 cites W2030907978 @default.
- W2603204608 cites W2038836473 @default.
- W2603204608 cites W2041811289 @default.
- W2603204608 cites W2047401805 @default.
- W2603204608 cites W2048376025 @default.
- W2603204608 cites W2053497547 @default.
- W2603204608 cites W2055494790 @default.
- W2603204608 cites W2055792599 @default.
- W2603204608 cites W2063206483 @default.
- W2603204608 cites W2065197926 @default.
- W2603204608 cites W2067137855 @default.
- W2603204608 cites W2067951272 @default.
- W2603204608 cites W2069519394 @default.
- W2603204608 cites W2069785923 @default.
- W2603204608 cites W2070816084 @default.
- W2603204608 cites W2077685680 @default.
- W2603204608 cites W2080094749 @default.
- W2603204608 cites W2080766885 @default.
- W2603204608 cites W2083268673 @default.
- W2603204608 cites W2083914055 @default.
- W2603204608 cites W2084822857 @default.
- W2603204608 cites W2085950149 @default.
- W2603204608 cites W2101276900 @default.
- W2603204608 cites W2101868966 @default.
- W2603204608 cites W2107800293 @default.
- W2603204608 cites W2110492953 @default.
- W2603204608 cites W2111322904 @default.
- W2603204608 cites W2112563127 @default.
- W2603204608 cites W2116787167 @default.
- W2603204608 cites W2120707458 @default.
- W2603204608 cites W2121232254 @default.
- W2603204608 cites W2126525177 @default.
- W2603204608 cites W2126563499 @default.
- W2603204608 cites W2127019230 @default.
- W2603204608 cites W2128655116 @default.
- W2603204608 cites W2128705781 @default.
- W2603204608 cites W2130016073 @default.
- W2603204608 cites W2130171501 @default.
- W2603204608 cites W2130458932 @default.
- W2603204608 cites W2137874618 @default.
- W2603204608 cites W2138498601 @default.
- W2603204608 cites W2141707708 @default.
- W2603204608 cites W2142454421 @default.
- W2603204608 cites W2144169031 @default.
- W2603204608 cites W2144695921 @default.
- W2603204608 cites W2148094237 @default.
- W2603204608 cites W2149010238 @default.
- W2603204608 cites W2149863676 @default.
- W2603204608 cites W2150344886 @default.
- W2603204608 cites W2150621637 @default.
- W2603204608 cites W2150748567 @default.
- W2603204608 cites W2152254080 @default.