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- W2603234451 abstract "e19004 Background: To compare the quality-adjusted survival of nab-PC vs sb-PC in first-line advanced NSCLC, the Q-TWiST methodology was applied to a Phase 3 randomized clinical trial which showed a significantly higher ORR, the primary endpoint, and non-inferior PFS and OS for nab-PC (Socinski et al, 2012). Methods: OS was partitioned into time: before disease progression without grade ≥ 3 toxicity (TWiST); with grade ≥ 3 toxicity (TOX); and after progression (REL). Mean Q-TWiST was calculated by multiplying the time spent in each state by utilities to estimate the quality-adjusted OS. In the base case, the health state utilities were assigned TWiST=1; TOX=0.5; REL=0.5. In threshold analyses, TOX and REL utilities were varied from 0 to 1. Comparisons between treatments were made for the intent-to-treat (ITT) population and subgroups by age, region, histology, and stage. Nonparametric bootstrap 95% CIs were derived to assess the statistical significance of differences in Q-TWiST. A relative gain in Q-TWiS..." @default.
- W2603234451 created "2017-04-07" @default.
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- W2603234451 date "2014-05-20" @default.
- W2603234451 modified "2023-09-25" @default.
- W2603234451 title "A quality-adjusted time without symptoms or toxicity (Q-TWiST) analysis comparing nab-paclitaxel plus carboplatin (nab-PC) with solvent-based paclitaxel plus carboplatin (sb-PC) in first-line advanced non-small cell lung cancer (NSCLC)." @default.
- W2603234451 doi "https://doi.org/10.1200/jco.2014.32.15_suppl.e19004" @default.
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