Matches in SemOpenAlex for { <https://semopenalex.org/work/W2603265890> ?p ?o ?g. }
- W2603265890 endingPage "e2705" @default.
- W2603265890 startingPage "e2705" @default.
- W2603265890 abstract "Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein implicated in the pathogenesis of acute respiratory distress syndrome, aging, cancer, coronary heart diseases, diabetes, nonalcoholic fatty liver disease, obesity, rheumatoid arthritis, and sepsis. However, the underlying molecular mechanisms of NAMPT in these physiological and pathological processes are not fully understood. Here, we provide experimental evidence that a Nampt gene homozygous knockout (Nampt-/-) resulted in lethality at an early stage of mouse embryonic development and death within 5-10 days in adult mice accompanied by a 25.24±2.22% body weight loss, after the tamoxifen induction of NamptF/F × Cre mice. These results substantiate that Nampt is an essential gene for life. In Nampt-/- mice versus Nampt+/+ mice, biochemical assays indicated that liver and intestinal tissue NAD levels were decreased significantly; histological examination showed that mouse intestinal villi were atrophic and disrupted, and visceral fat was depleted; mass spectrometry detected unusual higher serum polyunsaturated fatty acid containing triglycerides. RNA-seq analyses of both mouse and human pediatric liver transcriptomes have convergently revealed that NAMPT is involved in key basic cellular functions such as transcription, translation, cell signaling, and fundamental metabolism. Notably, the expression of all eight enzymes in the tricarboxylic acid cycle were decreased significantly in the Nampt-/- mice. These findings prompt us to posit that adult Nampt-/- mouse lethality is a result of a short supply of ATP from compromised intestinal absorption of nutrients from digested food, which leads to the exhaustion of body fat stores." @default.
- W2603265890 created "2017-04-07" @default.
- W2603265890 creator A5005624600 @default.
- W2603265890 creator A5020326010 @default.
- W2603265890 creator A5029784279 @default.
- W2603265890 creator A5035934482 @default.
- W2603265890 creator A5036726416 @default.
- W2603265890 creator A5037632148 @default.
- W2603265890 creator A5040985013 @default.
- W2603265890 creator A5046770954 @default.
- W2603265890 creator A5048345455 @default.
- W2603265890 creator A5051956542 @default.
- W2603265890 creator A5055843195 @default.
- W2603265890 creator A5057916843 @default.
- W2603265890 creator A5062021652 @default.
- W2603265890 creator A5072779805 @default.
- W2603265890 creator A5075391403 @default.
- W2603265890 creator A5084693085 @default.
- W2603265890 date "2017-03-23" @default.
- W2603265890 modified "2023-10-10" @default.
- W2603265890 title "Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase" @default.
- W2603265890 cites W1934704664 @default.
- W2603265890 cites W1973077186 @default.
- W2603265890 cites W1981509058 @default.
- W2603265890 cites W1992913613 @default.
- W2603265890 cites W1995766860 @default.
- W2603265890 cites W1997664301 @default.
- W2603265890 cites W2002811789 @default.
- W2603265890 cites W2003701712 @default.
- W2603265890 cites W2003924072 @default.
- W2603265890 cites W2011125600 @default.
- W2603265890 cites W2020262164 @default.
- W2603265890 cites W2026814500 @default.
- W2603265890 cites W2036072875 @default.
- W2603265890 cites W2047072851 @default.
- W2603265890 cites W2049628752 @default.
- W2603265890 cites W2065706325 @default.
- W2603265890 cites W2076633494 @default.
- W2603265890 cites W2080152761 @default.
- W2603265890 cites W2086553882 @default.
- W2603265890 cites W2096960190 @default.
- W2603265890 cites W2098419930 @default.
- W2603265890 cites W2104532843 @default.
- W2603265890 cites W2105830710 @default.
- W2603265890 cites W2106910438 @default.
- W2603265890 cites W2108536847 @default.
- W2603265890 cites W2113140044 @default.
- W2603265890 cites W2113734114 @default.
- W2603265890 cites W2118647245 @default.
- W2603265890 cites W2121445258 @default.
- W2603265890 cites W2125997801 @default.
- W2603265890 cites W2135110328 @default.
- W2603265890 cites W2151603546 @default.
- W2603265890 cites W2155395152 @default.
- W2603265890 cites W2155867477 @default.
- W2603265890 cites W2158217645 @default.
- W2603265890 cites W2167376541 @default.
- W2603265890 cites W2170173760 @default.
- W2603265890 cites W2174179366 @default.
- W2603265890 cites W2174686320 @default.
- W2603265890 cites W2177987001 @default.
- W2603265890 cites W2180291937 @default.
- W2603265890 cites W2229202799 @default.
- W2603265890 cites W4231082968 @default.
- W2603265890 doi "https://doi.org/10.1038/cddis.2017.132" @default.
- W2603265890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5386535" @default.
- W2603265890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28333140" @default.
- W2603265890 hasPublicationYear "2017" @default.
- W2603265890 type Work @default.
- W2603265890 sameAs 2603265890 @default.
- W2603265890 citedByCount "49" @default.
- W2603265890 countsByYear W26032658902017 @default.
- W2603265890 countsByYear W26032658902018 @default.
- W2603265890 countsByYear W26032658902019 @default.
- W2603265890 countsByYear W26032658902020 @default.
- W2603265890 countsByYear W26032658902021 @default.
- W2603265890 countsByYear W26032658902022 @default.
- W2603265890 countsByYear W26032658902023 @default.
- W2603265890 crossrefType "journal-article" @default.
- W2603265890 hasAuthorship W2603265890A5005624600 @default.
- W2603265890 hasAuthorship W2603265890A5020326010 @default.
- W2603265890 hasAuthorship W2603265890A5029784279 @default.
- W2603265890 hasAuthorship W2603265890A5035934482 @default.
- W2603265890 hasAuthorship W2603265890A5036726416 @default.
- W2603265890 hasAuthorship W2603265890A5037632148 @default.
- W2603265890 hasAuthorship W2603265890A5040985013 @default.
- W2603265890 hasAuthorship W2603265890A5046770954 @default.
- W2603265890 hasAuthorship W2603265890A5048345455 @default.
- W2603265890 hasAuthorship W2603265890A5051956542 @default.
- W2603265890 hasAuthorship W2603265890A5055843195 @default.
- W2603265890 hasAuthorship W2603265890A5057916843 @default.
- W2603265890 hasAuthorship W2603265890A5062021652 @default.
- W2603265890 hasAuthorship W2603265890A5072779805 @default.
- W2603265890 hasAuthorship W2603265890A5075391403 @default.
- W2603265890 hasAuthorship W2603265890A5084693085 @default.
- W2603265890 hasBestOaLocation W26032658901 @default.
- W2603265890 hasConcept C104317684 @default.
- W2603265890 hasConcept C126322002 @default.