Matches in SemOpenAlex for { <https://semopenalex.org/work/W2603454803> ?p ?o ?g. }
- W2603454803 endingPage "100" @default.
- W2603454803 startingPage "91" @default.
- W2603454803 abstract "Biliary tract cancer (BTC) is a heterogeneous group of cancers, which is composed of intrahepatic cholangiocarcinoma (ICCA), extrahepatic cholangiocarcinoma (ECCA), gallbladder cancers and ampullary carcinomas. While all anatomic subgroups are treated uniformly, our understanding about the pathogenesis has allowed us to reason that each group represents a clinically and genetically diverse disease. The majority of patients present with locally advanced or metastatic disease, where the standard treatment is combination systemic cytotoxic chemotherapy with gemcitabine and cisplatin. While most receive a clinical benefit from chemotherapy, patients eventually progress where no standardized therapies are available in the refractory setting. With the use of next generation sequencing, we have come to understand that ICCA is a diverse genomic disease with many actionable alterations that may serve as potential therapeutic targets. Further studies investigating the role of novel targeted agents (as a single agent or with combination chemotherapy) will hopefully provide additional treatment options for this highly lethal disease." @default.
- W2603454803 created "2017-04-07" @default.
- W2603454803 creator A5011930997 @default.
- W2603454803 creator A5064791048 @default.
- W2603454803 creator A5074891676 @default.
- W2603454803 date "2017-04-01" @default.
- W2603454803 modified "2023-10-01" @default.
- W2603454803 title "Therapeutic options for intrahepatic cholangiocarcinoma" @default.
- W2603454803 cites W1508721479 @default.
- W2603454803 cites W155535910 @default.
- W2603454803 cites W1891651361 @default.
- W2603454803 cites W1970368087 @default.
- W2603454803 cites W1974564771 @default.
- W2603454803 cites W1979296768 @default.
- W2603454803 cites W1983753579 @default.
- W2603454803 cites W1989236133 @default.
- W2603454803 cites W1990626198 @default.
- W2603454803 cites W1991701933 @default.
- W2603454803 cites W1995783757 @default.
- W2603454803 cites W1999642156 @default.
- W2603454803 cites W2000071834 @default.
- W2603454803 cites W2007555374 @default.
- W2603454803 cites W2008777301 @default.
- W2603454803 cites W2015613033 @default.
- W2603454803 cites W2018041848 @default.
- W2603454803 cites W2020956724 @default.
- W2603454803 cites W2022873103 @default.
- W2603454803 cites W2023155652 @default.
- W2603454803 cites W2025183385 @default.
- W2603454803 cites W2025769688 @default.
- W2603454803 cites W2033161279 @default.
- W2603454803 cites W2042048917 @default.
- W2603454803 cites W2053954823 @default.
- W2603454803 cites W2058770031 @default.
- W2603454803 cites W2062138514 @default.
- W2603454803 cites W2062328228 @default.
- W2603454803 cites W2062628269 @default.
- W2603454803 cites W2063300380 @default.
- W2603454803 cites W2063515380 @default.
- W2603454803 cites W2064626198 @default.
- W2603454803 cites W2065756402 @default.
- W2603454803 cites W2075637310 @default.
- W2603454803 cites W2076127799 @default.
- W2603454803 cites W2084530595 @default.
- W2603454803 cites W2087336559 @default.
- W2603454803 cites W2093388808 @default.
- W2603454803 cites W2093996140 @default.
- W2603454803 cites W2094337993 @default.
- W2603454803 cites W2094501197 @default.
- W2603454803 cites W2094518752 @default.
- W2603454803 cites W2096888043 @default.
- W2603454803 cites W2097924418 @default.
- W2603454803 cites W2100439220 @default.
- W2603454803 cites W2101036284 @default.
- W2603454803 cites W2101637122 @default.
- W2603454803 cites W2102539343 @default.
- W2603454803 cites W2103198051 @default.
- W2603454803 cites W2108756633 @default.
- W2603454803 cites W2113222623 @default.
- W2603454803 cites W2113988779 @default.
- W2603454803 cites W2114327118 @default.
- W2603454803 cites W2115261608 @default.
- W2603454803 cites W2115288936 @default.
- W2603454803 cites W2117611914 @default.
- W2603454803 cites W2118520585 @default.
- W2603454803 cites W2126983598 @default.
- W2603454803 cites W2128889451 @default.
- W2603454803 cites W2132215313 @default.
- W2603454803 cites W2135078662 @default.
- W2603454803 cites W2136264959 @default.
- W2603454803 cites W2136797122 @default.
- W2603454803 cites W2139947970 @default.
- W2603454803 cites W2145857211 @default.
- W2603454803 cites W2148899606 @default.
- W2603454803 cites W2154711900 @default.
- W2603454803 cites W2159967578 @default.
- W2603454803 cites W2168106806 @default.
- W2603454803 cites W2169332099 @default.
- W2603454803 cites W2170598509 @default.
- W2603454803 cites W2171559250 @default.
- W2603454803 cites W2252843566 @default.
- W2603454803 cites W2338431914 @default.
- W2603454803 cites W2341530806 @default.
- W2603454803 cites W2343618896 @default.
- W2603454803 cites W2401765700 @default.
- W2603454803 cites W2410415245 @default.
- W2603454803 doi "https://doi.org/10.21037/hbsn.2016.12.12" @default.
- W2603454803 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5411274" @default.
- W2603454803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28503556" @default.
- W2603454803 hasPublicationYear "2017" @default.
- W2603454803 type Work @default.
- W2603454803 sameAs 2603454803 @default.
- W2603454803 citedByCount "11" @default.
- W2603454803 countsByYear W26034548032018 @default.
- W2603454803 countsByYear W26034548032020 @default.
- W2603454803 countsByYear W26034548032021 @default.
- W2603454803 countsByYear W26034548032022 @default.
- W2603454803 countsByYear W26034548032023 @default.