Matches in SemOpenAlex for { <https://semopenalex.org/work/W2603803144> ?p ?o ?g. }
- W2603803144 abstract "Allelic exclusion describes the essential immunological process by which feedback repression of sequential DNA rearrangements ensures that only one autosome expresses a functional T or B cell receptor. In wild-type mammals, approximately 60% of cells have recombined the DNA of one T cell receptor β (TCRβ) V-to-DJ-joined allele in a functional configuration, while the second allele has recombined only the DJ sequences; the other 40% of cells have recombined the V to the DJ segments on both alleles, with only one of the two alleles predicting a functional TCRβ protein. Here we report that the transgenic overexpression of GATA3 leads predominantly to biallelic TCRβ gene (Tcrb) recombination. We also found that wild-type immature thymocytes can be separated into distinct populations based on intracellular GATA3 expression and that GATA3LO cells had almost exclusively recombined only one Tcrb locus (that predicted a functional receptor sequence), while GATA3HI cells had uniformly recombined both Tcrb alleles (one predicting a functional and the other predicting a nonfunctional rearrangement). These data show that GATA3 abundance regulates the recombination propensity at the Tcrb locus and provide new mechanistic insight into the historic immunological conundrum for how Tcrb allelic exclusion is mediated." @default.
- W2603803144 created "2017-04-07" @default.
- W2603803144 creator A5011032655 @default.
- W2603803144 creator A5012832644 @default.
- W2603803144 creator A5020858260 @default.
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- W2603803144 creator A5048706550 @default.
- W2603803144 creator A5052698930 @default.
- W2603803144 date "2017-06-01" @default.
- W2603803144 modified "2023-10-16" @default.
- W2603803144 title "GATA3 Abundance Is a Critical Determinant of T Cell Receptor <i>β</i> Allelic Exclusion" @default.
- W2603803144 cites W121129899 @default.
- W2603803144 cites W1521285578 @default.
- W2603803144 cites W1525824369 @default.
- W2603803144 cites W1530738338 @default.
- W2603803144 cites W1605591220 @default.
- W2603803144 cites W1668774261 @default.
- W2603803144 cites W1823105344 @default.
- W2603803144 cites W1848816727 @default.
- W2603803144 cites W1893591766 @default.
- W2603803144 cites W1946088674 @default.
- W2603803144 cites W1965285817 @default.
- W2603803144 cites W1971359363 @default.
- W2603803144 cites W1981344753 @default.
- W2603803144 cites W1981611424 @default.
- W2603803144 cites W1989604593 @default.
- W2603803144 cites W1990159938 @default.
- W2603803144 cites W1993090087 @default.
- W2603803144 cites W1995530329 @default.
- W2603803144 cites W1996247810 @default.
- W2603803144 cites W1996822762 @default.
- W2603803144 cites W1996835556 @default.
- W2603803144 cites W1998662278 @default.
- W2603803144 cites W1999331935 @default.
- W2603803144 cites W1999388807 @default.
- W2603803144 cites W2000779612 @default.
- W2603803144 cites W2002817805 @default.
- W2603803144 cites W2006182924 @default.
- W2603803144 cites W2007359758 @default.
- W2603803144 cites W2008027390 @default.
- W2603803144 cites W2010302579 @default.
- W2603803144 cites W2010760683 @default.
- W2603803144 cites W2023724701 @default.
- W2603803144 cites W2025336339 @default.
- W2603803144 cites W2026129212 @default.
- W2603803144 cites W2027996732 @default.
- W2603803144 cites W2033708892 @default.
- W2603803144 cites W2044001333 @default.
- W2603803144 cites W2050184590 @default.
- W2603803144 cites W2055034718 @default.
- W2603803144 cites W2056429839 @default.
- W2603803144 cites W2058288999 @default.
- W2603803144 cites W2059113040 @default.
- W2603803144 cites W2059260080 @default.
- W2603803144 cites W2061307900 @default.
- W2603803144 cites W2063666648 @default.
- W2603803144 cites W2063957967 @default.
- W2603803144 cites W2068012172 @default.
- W2603803144 cites W2069426612 @default.
- W2603803144 cites W2071532361 @default.
- W2603803144 cites W2071969437 @default.
- W2603803144 cites W2079290252 @default.
- W2603803144 cites W2085146674 @default.
- W2603803144 cites W2085369521 @default.
- W2603803144 cites W2094457561 @default.
- W2603803144 cites W2096313716 @default.
- W2603803144 cites W2100305481 @default.
- W2603803144 cites W2103788710 @default.
- W2603803144 cites W2104089904 @default.
- W2603803144 cites W2109141013 @default.
- W2603803144 cites W2114724040 @default.
- W2603803144 cites W2115238064 @default.
- W2603803144 cites W2119709204 @default.
- W2603803144 cites W2122140726 @default.
- W2603803144 cites W2125601665 @default.
- W2603803144 cites W2125764747 @default.
- W2603803144 cites W2126464081 @default.
- W2603803144 cites W2137898919 @default.
- W2603803144 cites W2140729960 @default.
- W2603803144 cites W2149582300 @default.
- W2603803144 cites W2151396228 @default.
- W2603803144 cites W2157536177 @default.
- W2603803144 cites W2157808247 @default.
- W2603803144 cites W2158217645 @default.
- W2603803144 cites W2166723948 @default.
- W2603803144 cites W2170064419 @default.
- W2603803144 cites W2170694208 @default.
- W2603803144 cites W2188189445 @default.
- W2603803144 cites W2254523882 @default.
- W2603803144 cites W2258207141 @default.
- W2603803144 cites W2518654183 @default.
- W2603803144 cites W2578150941 @default.
- W2603803144 cites W31476814 @default.
- W2603803144 cites W4211183651 @default.
- W2603803144 cites W4252461177 @default.
- W2603803144 cites W4313342477 @default.
- W2603803144 doi "https://doi.org/10.1128/mcb.00052-17" @default.