Matches in SemOpenAlex for { <https://semopenalex.org/work/W2603854911> ?p ?o ?g. }
- W2603854911 endingPage "30454" @default.
- W2603854911 startingPage "30438" @default.
- W2603854911 abstract "mTOR activation suppresses autophagy by phosphorylating ULK1 at S757 and suppressing its enzymatic activity. Here we report that feedback activation of mTOR in the PI-3 kinase pathway by two p70 S6 kinase (S6K1) inhibitors (PF-4708671 and A77 1726, the active metabolite of an immunosuppressive drug leflunomide) or by S6K1 knockdown did not suppress but rather induced autophagy. Suppression of S6K1 activity led to the phosphorylation and activation of AMPK, which then phosphorylated ULK1 at S555. While mTOR feedback activation led to increased phosphorylation of ULK1 at S757, this modification did not the disrupt ULK1-AMPK interaction nor dampen ULK1 S555 phosphorylation and the induction of autophagy. In addition, inhibition of S6K1 activity led to JNK activation, which also contributed to autophagy. 5Z-7-oxozeaenol, a specific inhibitor of TAK1, or TAK1 siRNA blocked A77 1726-induced activation of AMPK and JNK, and LC3 lipidation. Taken together, our study establishes S6K1 as a key player in the PI-3 kinase pathway to suppress autophagy through inhibiting AMPK and JNK in a TAK1-dependent manner." @default.
- W2603854911 created "2017-04-07" @default.
- W2603854911 creator A5032575460 @default.
- W2603854911 creator A5036315389 @default.
- W2603854911 creator A5050837761 @default.
- W2603854911 creator A5051937473 @default.
- W2603854911 creator A5060590787 @default.
- W2603854911 creator A5063784142 @default.
- W2603854911 creator A5064181653 @default.
- W2603854911 creator A5064842058 @default.
- W2603854911 creator A5082437367 @default.
- W2603854911 creator A5084282975 @default.
- W2603854911 date "2017-03-31" @default.
- W2603854911 modified "2023-10-15" @default.
- W2603854911 title "Inhibition of p70 S6 kinase (S6K1) activity by A77 1726, the active metabolite of leflunomide, induces autophagy through TAK1-mediated AMPK and JNK activation" @default.
- W2603854911 cites W1967704295 @default.
- W2603854911 cites W1969393277 @default.
- W2603854911 cites W1970637701 @default.
- W2603854911 cites W1975924645 @default.
- W2603854911 cites W1999143228 @default.
- W2603854911 cites W2000614504 @default.
- W2603854911 cites W2008955645 @default.
- W2603854911 cites W2013381376 @default.
- W2603854911 cites W2014892893 @default.
- W2603854911 cites W2016752484 @default.
- W2603854911 cites W2024303872 @default.
- W2603854911 cites W2025935112 @default.
- W2603854911 cites W2026094543 @default.
- W2603854911 cites W2028038518 @default.
- W2603854911 cites W2031655911 @default.
- W2603854911 cites W2037323859 @default.
- W2603854911 cites W2046822015 @default.
- W2603854911 cites W2047977738 @default.
- W2603854911 cites W2052054022 @default.
- W2603854911 cites W2064439294 @default.
- W2603854911 cites W2066194653 @default.
- W2603854911 cites W2067156757 @default.
- W2603854911 cites W2070782085 @default.
- W2603854911 cites W2070871404 @default.
- W2603854911 cites W2074377887 @default.
- W2603854911 cites W2075006858 @default.
- W2603854911 cites W2075335654 @default.
- W2603854911 cites W2077671506 @default.
- W2603854911 cites W2080390339 @default.
- W2603854911 cites W2081706292 @default.
- W2603854911 cites W2088855154 @default.
- W2603854911 cites W2092503451 @default.
- W2603854911 cites W2097830998 @default.
- W2603854911 cites W2101220947 @default.
- W2603854911 cites W2103659405 @default.
- W2603854911 cites W2107674876 @default.
- W2603854911 cites W2113526794 @default.
- W2603854911 cites W2119041481 @default.
- W2603854911 cites W2120144499 @default.
- W2603854911 cites W2120348861 @default.
- W2603854911 cites W2121429373 @default.
- W2603854911 cites W2125025556 @default.
- W2603854911 cites W2131333624 @default.
- W2603854911 cites W2134106182 @default.
- W2603854911 cites W2143017085 @default.
- W2603854911 cites W2150595264 @default.
- W2603854911 cites W2157638939 @default.
- W2603854911 cites W2160615487 @default.
- W2603854911 cites W2163961147 @default.
- W2603854911 cites W2207044403 @default.
- W2603854911 cites W2461774736 @default.
- W2603854911 cites W55510815 @default.
- W2603854911 cites W88786743 @default.
- W2603854911 doi "https://doi.org/10.18632/oncotarget.16737" @default.
- W2603854911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5444754" @default.
- W2603854911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28389629" @default.
- W2603854911 hasPublicationYear "2017" @default.
- W2603854911 type Work @default.
- W2603854911 sameAs 2603854911 @default.
- W2603854911 citedByCount "23" @default.
- W2603854911 countsByYear W26038549112018 @default.
- W2603854911 countsByYear W26038549112019 @default.
- W2603854911 countsByYear W26038549112020 @default.
- W2603854911 countsByYear W26038549112021 @default.
- W2603854911 countsByYear W26038549112022 @default.
- W2603854911 countsByYear W26038549112023 @default.
- W2603854911 crossrefType "journal-article" @default.
- W2603854911 hasAuthorship W2603854911A5032575460 @default.
- W2603854911 hasAuthorship W2603854911A5036315389 @default.
- W2603854911 hasAuthorship W2603854911A5050837761 @default.
- W2603854911 hasAuthorship W2603854911A5051937473 @default.
- W2603854911 hasAuthorship W2603854911A5060590787 @default.
- W2603854911 hasAuthorship W2603854911A5063784142 @default.
- W2603854911 hasAuthorship W2603854911A5064181653 @default.
- W2603854911 hasAuthorship W2603854911A5064842058 @default.
- W2603854911 hasAuthorship W2603854911A5082437367 @default.
- W2603854911 hasAuthorship W2603854911A5084282975 @default.
- W2603854911 hasBestOaLocation W26038549111 @default.
- W2603854911 hasConcept C104202773 @default.
- W2603854911 hasConcept C11960822 @default.
- W2603854911 hasConcept C126322002 @default.
- W2603854911 hasConcept C149151106 @default.
- W2603854911 hasConcept C184235292 @default.