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• W2603971331 abstract "// Dong-Xu Han 1 , Xu-Lei Sun 1 , Ming-Qiang Xu 1 , Cheng-Zhen Chen 1 , Hao Jiang 1 , Yan Gao 1 , Bao Yuan 1 and Jia-Bao Zhang 1 1 Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun, Jilin, P.R. China Correspondence to: Jia-Bao Zhang, email: zjb515@126.com Bao Yuan, email: yuanbao1982@163.com Keywords: rat anterior pituitary cell, FSH secretion, miR-21-3p, miR-433, animal reproduction Received: February 06, 2017     Accepted: March 11, 2017     Published: March 28, 2017 ABSTRACT Follicle-stimulating hormone (FSH) secreted by adenohypophyseal cells plays an important role in the regulation of reproduction, but whether microRNAs (miRNAs) regulate the secretion of FSH remains unclear. In the present study, we predicted and screened miRNAs that might act on the follicle-stimulating hormone beta-subunit (FSHb) gene of rats using the TargetScan program and luciferase reporter assays, and the results identified two miRNAs, miR-21-3p and miR-433. We then transfected these miRNAs into rat anterior adenohypophyseal cells and assessed the FSHb expression levels in and FSH secretion by the transfected cells through quantitative PCR and ELISA. The results showed that both miR-21-3p and miR-433 down-regulated the expression levels of FSHb and resulted in the decrease of the secretion of FSH compared with the control group, and treatment with miR-21-3p and miR-433 inhibitors up-regulated the expression levels of FSHb and resulted in the increase of the secretion of FSH. Taken together, our results indicate that miR-21-3p and miR-433 can down-regulate the expression of FSHb by directly targeting the FSHb 3’UTR in rat primary pituitary cells. Our findings provide evidence that miRNAs can regulate FSHb expression and further affect the secretion of FSH and might contribute to the use of miRNAs for the regulation of animal reproduction." @default.
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• W2603971331 date "2017-03-28" @default.
• W2603971331 modified "2023-10-14" @default.
• W2603971331 title "Roles of differential expression of microRNA-21-3p and microRNA-433 in FSH regulation in rat anterior pituitary cells" @default.
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• W2603971331 doi "https://doi.org/10.18632/oncotarget.16615" @default.
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