Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604022045> ?p ?o ?g. }
- W2604022045 endingPage "e3976" @default.
- W2604022045 startingPage "e3976" @default.
- W2604022045 abstract "The aim of this study was to develop and validate fully the liquid chromatography-tandem mass spectrometry method for free mycophenolic acid (MPA) concentration measurements in plasma ultrafiltrate that will be reliable and simple in preparation with deuterated MPA (MPA-d3) chosen as an internal standard. The chromatographic separation was made with Zorbax Eclipse XDB-C18 column (4.6 × 150 mm) using a gradient of two solutions as a mobile phase: (A) water and (B) methanol, each containing 0.1% formic acid and 2.5 mm ammonium acetate. Satisfactory repeatability of retention times was achieved with average values of 7.54 ± 0.20 min and 7.50 ± 0.19 min for MPA and MPA-d3, respectively. The method was selective, with no carry-over or matrix effect observed. The analytical range was proven for MPA ultrafiltrate concentrations of 1-500 ng/mL. The accuracy and precision fell within the acceptance criteria for intraday (accuracy: 100.63-110.46%, imprecision: 6.23-7.76%), as well as interday assay (accuracy: 98.81-110.63%; imprecision: 5.36-10.22%). The method was used for free MPA determination in plasma samples from patients treated with mycophenolate mofetil. To the best of our knowledge this is the first liquid chromatography-tandem mass spectrometry method for free MPA monitoring using MPA-d3 that allows to measure plasma ultrafiltrate concentrations as low as 1 ng/mL." @default.
- W2604022045 created "2017-04-07" @default.
- W2604022045 creator A5047646062 @default.
- W2604022045 creator A5055578452 @default.
- W2604022045 creator A5055631408 @default.
- W2604022045 creator A5062306370 @default.
- W2604022045 creator A5063202681 @default.
- W2604022045 date "2017-05-21" @default.
- W2604022045 modified "2023-10-13" @default.
- W2604022045 title "Free mycophenolic acid determination in human plasma ultrafiltrate by a validated liquid chromatography-tandem mass spectrometry method" @default.
- W2604022045 cites W1578125032 @default.
- W2604022045 cites W1742548498 @default.
- W2604022045 cites W1978827614 @default.
- W2604022045 cites W1980201472 @default.
- W2604022045 cites W1983231241 @default.
- W2604022045 cites W1987157441 @default.
- W2604022045 cites W1987585306 @default.
- W2604022045 cites W1988799797 @default.
- W2604022045 cites W1991050287 @default.
- W2604022045 cites W1992869106 @default.
- W2604022045 cites W2000729031 @default.
- W2604022045 cites W2003335099 @default.
- W2604022045 cites W2006198853 @default.
- W2604022045 cites W2011720547 @default.
- W2604022045 cites W2019038379 @default.
- W2604022045 cites W2019603280 @default.
- W2604022045 cites W2019607300 @default.
- W2604022045 cites W2023106874 @default.
- W2604022045 cites W2027688584 @default.
- W2604022045 cites W2029830810 @default.
- W2604022045 cites W2031472196 @default.
- W2604022045 cites W2031904689 @default.
- W2604022045 cites W2043912873 @default.
- W2604022045 cites W2046396835 @default.
- W2604022045 cites W205301961 @default.
- W2604022045 cites W2055178445 @default.
- W2604022045 cites W2056054156 @default.
- W2604022045 cites W2059314221 @default.
- W2604022045 cites W2067678559 @default.
- W2604022045 cites W2069843526 @default.
- W2604022045 cites W2080352488 @default.
- W2604022045 cites W2087765915 @default.
- W2604022045 cites W2088679304 @default.
- W2604022045 cites W2105890101 @default.
- W2604022045 cites W2116480833 @default.
- W2604022045 cites W2132647543 @default.
- W2604022045 cites W2167315642 @default.
- W2604022045 cites W2172121516 @default.
- W2604022045 cites W2314014464 @default.
- W2604022045 cites W2317114677 @default.
- W2604022045 cites W2327939347 @default.
- W2604022045 cites W2498230230 @default.
- W2604022045 cites W4245052018 @default.
- W2604022045 cites W560926806 @default.
- W2604022045 cites W64263188 @default.
- W2604022045 doi "https://doi.org/10.1002/bmc.3976" @default.
- W2604022045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28317135" @default.
- W2604022045 hasPublicationYear "2017" @default.
- W2604022045 type Work @default.
- W2604022045 sameAs 2604022045 @default.
- W2604022045 citedByCount "9" @default.
- W2604022045 countsByYear W26040220452018 @default.
- W2604022045 countsByYear W26040220452019 @default.
- W2604022045 countsByYear W26040220452020 @default.
- W2604022045 countsByYear W26040220452021 @default.
- W2604022045 countsByYear W26040220452023 @default.
- W2604022045 crossrefType "journal-article" @default.
- W2604022045 hasAuthorship W2604022045A5047646062 @default.
- W2604022045 hasAuthorship W2604022045A5055578452 @default.
- W2604022045 hasAuthorship W2604022045A5055631408 @default.
- W2604022045 hasAuthorship W2604022045A5062306370 @default.
- W2604022045 hasAuthorship W2604022045A5063202681 @default.
- W2604022045 hasConcept C154020017 @default.
- W2604022045 hasConcept C162356407 @default.
- W2604022045 hasConcept C179998833 @default.
- W2604022045 hasConcept C185592680 @default.
- W2604022045 hasConcept C2777379063 @default.
- W2604022045 hasConcept C2780782300 @default.
- W2604022045 hasConcept C31827203 @default.
- W2604022045 hasConcept C43617362 @default.
- W2604022045 hasConcept C64489805 @default.
- W2604022045 hasConcept C71043704 @default.
- W2604022045 hasConceptScore W2604022045C154020017 @default.
- W2604022045 hasConceptScore W2604022045C162356407 @default.
- W2604022045 hasConceptScore W2604022045C179998833 @default.
- W2604022045 hasConceptScore W2604022045C185592680 @default.
- W2604022045 hasConceptScore W2604022045C2777379063 @default.
- W2604022045 hasConceptScore W2604022045C2780782300 @default.
- W2604022045 hasConceptScore W2604022045C31827203 @default.
- W2604022045 hasConceptScore W2604022045C43617362 @default.
- W2604022045 hasConceptScore W2604022045C64489805 @default.
- W2604022045 hasConceptScore W2604022045C71043704 @default.
- W2604022045 hasFunder F4320322412 @default.
- W2604022045 hasIssue "10" @default.
- W2604022045 hasLocation W26040220451 @default.
- W2604022045 hasLocation W26040220452 @default.
- W2604022045 hasOpenAccess W2604022045 @default.
- W2604022045 hasPrimaryLocation W26040220451 @default.