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- W2604070189 abstract "110 Background: Primary or secondary resistance to Imatinib, convolutes the control of Gastrointestinal Stromal Tumors (GIST). We aimed to evaluate clinical outcomes of new tyrosine kinase inhibitors (TKIs) in the treatment of Imatinib resistant GIST. Methods: Online database search of PubMed, MEDLINE, EMBASE, SCOPUS, COCHRANE, and GOOGLE SCHOLAR was performed (2000– Present); key bibliographies were reviewed. Studies comparing patients with Imatinib resistant GIST who were treated with placebo versus new generation TKIs (Regorafenib, Sunitinib, Nilotinib). Primary outcomes were overall and progression free survival (OS, PFS), secondary outcomes include the most common side effects described in trials using new TKIs. Meta-analysis was conducted using Statistical Analysis System (SAS) software. Relative risks with the corresponding 95% confidence intervals (CI) by random effects models of pooled data were calculated. Study quality was assessed using JADAD scoring system. Results: Out of 16 studies, 4 studies met our selection criteria including 825 patients in total; 553 treated with new TKIs and 272 were given placebo (control group). Median age was 57.85 years. Meta-analysis of included data showed significantly improved PFS in the new TKIs group (HR = 0.336, 95% CI 0.208-0.542, p < 0.001.) Similar trend but without statistically significant difference was seen in OS (HR = 0.836, 95% CI 0.682-1.026, p = 0.086). Incidence of hypertension was found to be significantly higher in the new TKIs group (RR = 2.903, 95% CI 1.800-4.681, p < 0.001); the same effect was observed in development of hand foot syndrome (RR = 4.818, 95% CI 2.723-8.525, p < 0.001) and diarrhea (RR = 5.341, 95% CI 3.074-9.281, p < 0.001). Conclusions: New generation of TKIs significantly improved PFS compared with placebo in patients with Imatinib resistant GIST. However new TKIs have increased secondary side effects. Randomized controlled trials are needed to evaluate longer term outcomes of these treatments." @default.
- W2604070189 created "2017-04-07" @default.
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- W2604070189 date "2017-02-01" @default.
- W2604070189 modified "2023-09-27" @default.
- W2604070189 title "New tyrosine kinase inhibitors in the treatment of imatinib resistant GIST: An updated meta-analysis." @default.
- W2604070189 doi "https://doi.org/10.1200/jco.2017.35.4_suppl.110" @default.
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