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• W2604111152 abstract "Neutrophils infiltration in liver is one of the typical histological characteristics of nonalcoholic steato- hepatitis (NASH) in both animal models and human sub- jects. This study was aimed to investigate the role of neutrophils in the process of NASH and its underling mechanisms. C57BL/6J mice were fed with either standard chow (SC) or methionine/choline-deficient (MCD) diet for 1, 2, 4, 8 weeks, respectively. C57BL/6J APOE -/- mice were fed with SC or high-fat high-cholesterol (HFHC) diet. Anti-Ly6G antibody was employed to deplete neutrophils and sivelestat was used to inhibit neutrophil elastase (NE). MCD-diet-receiving mice with neutrophil depletion had much lower serum ALT activity, liver inflammation, and mRNA levels of proinflammatory genes in the early stage of NASH (1 and 2 weeks) when compared to non-neu- trophil-depleted mice. NE inhibitor sivelestat could reca- pitulate the effects of neutrophil depletion in APOE -/- mice fed with HFHC diet. As the disease progressed (4 and 8 weeks), neutrophil depletion did not lower serum ALT levels and liver lesions due to activation of Kupffer cells. Finally, we found neutrophils also affected anti-inflam- mation cytokine interleukin-1 receptor antagonist mRNA expression. Neutrophils play a crucial role in the early stage of NASH via NE." @default.
• W2604111152 created "2017-04-14" @default.
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• W2604111152 date "2015-01-01" @default.
• W2604111152 modified "2023-09-27" @default.
• W2604111152 title "Neutrophils Play a Crucial Role in the Early Stage of Nonalcoholic Steatohepatitis via Neutrophil Elastase in Mice" @default.
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