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- W2604115218 abstract "Phytochemical investigation of the stem bark of Campylospermum zenkeri led to the isolation of five known compounds: (Z,Z)-9,12-octadecadienoic acid (1), serotobenine (2), agathisflavone (3), lophirone A (4) and lophirone F (5), together with a new derivative of procyanidin B, a catechin dimer named zenkerinol (6). Serotobenine (2) is structurally related to decursivine which shows moderate activity against D6 and W2 strains of Plasmodium falciparum. For a better understanding of structure-activity relationships, three new semi-synthetic derivatives of serotobenine (2) have been prepared. These are: serotobenine monopropionate (2a), serotobenine monopivalate (2b) and serotobenine cyclohexyl ether (2c) respectively. Two of them (2a) and (2b), were evaluated for their antiplasmodial activity against P. falciparum 3D7 strain in a parasite lactate-dehydrogenase (pLDH) assay. Compound 2b was more active than compound 2a based on their IC50 values (36.6 and 123 μM, respectively)." @default.
- W2604115218 created "2017-04-14" @default.
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- W2604115218 date "2017-04-07" @default.
- W2604115218 modified "2023-10-03" @default.
- W2604115218 title "A new procyanidin B from <i>Campylospermum zenkeri</i> (Ochnaceae) and antiplasmodial activity of two derivatives of (±)-serotobenine" @default.
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- W2604115218 doi "https://doi.org/10.1080/14786419.2017.1305378" @default.
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