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• W2604128249 endingPage "e0005507" @default.
• W2604128249 startingPage "e0005507" @default.
• W2604128249 abstract "Oral transmission of Trypanosoma cruzi, the causative agent of Chagas disease, is the most important route of infection in Brazilian Amazon and Venezuela. Other South American countries have also reported outbreaks associated with food consumption. A recent study showed the importance of parasite contact with oral cavity to induce a highly severe acute disease in mice. However, it remains uncertain the primary site of parasite entry and multiplication due to an oral infection. Here, we evaluated the presence of T. cruzi Dm28c luciferase (Dm28c-luc) parasites in orally infected mice, by bioluminescence and quantitative real-time PCR. In vivo bioluminescent images indicated the nasomaxillary region as the site of parasite invasion in the host, becoming consistently infected throughout the acute phase. At later moments, 7 and 21 days post-infection (dpi), luminescent signal is denser in the thorax, abdomen and genital region, because of parasite dissemination in different tissues. Ex vivo analysis demonstrated that the nasomaxillary region, heart, mandibular lymph nodes, liver, spleen, brain, epididymal fat associated to male sex organs, salivary glands, cheek muscle, mesenteric fat and lymph nodes, stomach, esophagus, small and large intestine are target tissues at latter moments of infection. In the same line, amastigote nests of Dm28c GFP T. cruzi were detected in the nasal cavity of 6 dpi mice. Parasite quantification by real-time qPCR at 7 and 21 dpi showed predominant T. cruzi detection and expansion in mouse nasal cavity. Moreover, T. cruzi DNA was also observed in the mandibular lymph nodes, pituitary gland, heart, liver, small intestine and spleen at 7 dpi, and further, disseminated to other tissues, such as the brain, stomach, esophagus and large intestine at 21 dpi. Our results clearly demonstrated that oral cavity and adjacent compartments is the main target region in oral T. cruzi infection leading to parasite multiplication at the nasal cavity." @default.
• W2604128249 created "2017-04-14" @default.
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• W2604128249 date "2017-04-05" @default.
• W2604128249 modified "2023-10-14" @default.
• W2604128249 title "Unraveling Chagas disease transmission through the oral route: Gateways to Trypanosoma cruzi infection and target tissues" @default.
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• W2604128249 cites W157217215 @default.
• W2604128249 cites W1745179720 @default.
• W2604128249 cites W1832557653 @default.
• W2604128249 cites W1901605865 @default.
• W2604128249 cites W195767728 @default.
• W2604128249 cites W1964779113 @default.
• W2604128249 cites W1966506072 @default.
• W2604128249 cites W1972043575 @default.
• W2604128249 cites W1973707561 @default.
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• W2604128249 cites W1980372064 @default.
• W2604128249 cites W1984298847 @default.
• W2604128249 cites W1987653890 @default.
• W2604128249 cites W2004562596 @default.
• W2604128249 cites W2004748045 @default.
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• W2604128249 cites W2005188493 @default.
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• W2604128249 cites W2035841030 @default.
• W2604128249 cites W2038738570 @default.
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• W2604128249 cites W2045866351 @default.
• W2604128249 cites W2046238344 @default.
• W2604128249 cites W2065752585 @default.
• W2604128249 cites W2068742054 @default.
• W2604128249 cites W2071316624 @default.
• W2604128249 cites W2078960449 @default.
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• W2604128249 doi "https://doi.org/10.1371/journal.pntd.0005507" @default.
• W2604128249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5397068" @default.
• W2604128249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28379959" @default.
• W2604128249 hasPublicationYear "2017" @default.
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