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- W2604133615 abstract "In this study, the influence of sample matrix on the relative bioavailability of arsenic (As), cadmium (Cd) and lead (Pb) was assessed following exposure of C57BL/6 mice to spiked aged (12 years) soils. AIN93G mouse chow was amended with individual and tertiary As, Cd and Pb soil combinations which were administered to mice over a 9 day exposure period. Contaminant relative bioavailability was calculated by comparing As urinary excretion and Cd-kidney/Pb-liver accumulation to corresponding values for compounds used to derive the respective toxicity reference value. Strong linear dose-responses were observed for mice exposed to AIN93G mouse chow augmented with individually spiked soil with As, Cd and Pb. When mice were exposed to co-contaminants, As relative bioavailability (RBA) decreased similar to results from previous co-contaminant salt experiments presumably due to the influence of Cd on phosphate transport proteins, which are utilized for As absorption. However, a decrease in Cd-kidney and Pb-liver accumulation was also observed following co-co-exposure. It was postulated that this resulted from interactions with other (essential) metals (e.g. iron, aluminium, manganese, magnesium) within the soil matrix and their influence on absorption via divalent metal transporters." @default.
- W2604133615 created "2017-04-14" @default.
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- W2604133615 date "2017-10-01" @default.
- W2604133615 modified "2023-09-25" @default.
- W2604133615 title "Influence of sample matrix on the bioavailability of arsenic, cadmium and lead during co-contaminant exposure" @default.
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- W2604133615 doi "https://doi.org/10.1016/j.scitotenv.2017.04.036" @default.
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