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- W2604172498 abstract "Epilepsy-the propensity toward recurrent, unprovoked seizures-is a devastating disease affecting 65 million people worldwide. Understanding and treating this disease remains a challenge, as seizures manifest through mechanisms and features that span spatial and temporal scales. Here we address this challenge through the analysis and modelling of human brain voltage activity recorded simultaneously across microscopic and macroscopic spatial scales. We show that during seizure large-scale neural populations spanning centimetres of cortex coordinate with small neural groups spanning cortical columns, and provide evidence that rapidly propagating waves of activity underlie this increased inter-scale coupling. We develop a corresponding computational model to propose specific mechanisms-namely, the effects of an increased extracellular potassium concentration diffusing in space-that support the observed spatiotemporal dynamics. Understanding the multi-scale, spatiotemporal dynamics of human seizures-and connecting these dynamics to specific biological mechanisms-promises new insights to treat this devastating disease." @default.
- W2604172498 created "2017-04-14" @default.
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- W2604172498 date "2017-04-01" @default.
- W2604172498 modified "2023-10-16" @default.
- W2604172498 title "Human seizures couple across spatial scales through travelling wave dynamics" @default.
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- W2604172498 cites W1554576051 @default.
- W2604172498 cites W1617948373 @default.
- W2604172498 cites W1792676559 @default.
- W2604172498 cites W1809188141 @default.
- W2604172498 cites W1946443775 @default.
- W2604172498 cites W1970117905 @default.
- W2604172498 cites W1970604942 @default.
- W2604172498 cites W1976995170 @default.
- W2604172498 cites W1981082198 @default.
- W2604172498 cites W1985983039 @default.
- W2604172498 cites W1996657129 @default.
- W2604172498 cites W1997680969 @default.
- W2604172498 cites W2005123840 @default.
- W2604172498 cites W2009579332 @default.
- W2604172498 cites W2012059114 @default.
- W2604172498 cites W2013610014 @default.
- W2604172498 cites W2014059618 @default.
- W2604172498 cites W2028756092 @default.
- W2604172498 cites W2034457899 @default.
- W2604172498 cites W2036254630 @default.
- W2604172498 cites W2037627150 @default.
- W2604172498 cites W2039281962 @default.
- W2604172498 cites W2041935477 @default.
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- W2604172498 cites W2077457515 @default.
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- W2604172498 cites W2084473005 @default.
- W2604172498 cites W2085694179 @default.
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- W2604172498 cites W2089703347 @default.
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- W2604172498 doi "https://doi.org/10.1038/ncomms14896" @default.
- W2604172498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5382286" @default.
- W2604172498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28374740" @default.
- W2604172498 hasPublicationYear "2017" @default.
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