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• W2604184613 abstract "우리나라 경기북부지역은 말라리아 위험지역으로 말라리아는 주로 이 지역의 우점종인 Anopheles sinensis에 의해 감염되는 것으로 알려져 있다. 이들에 대한 방제는 주로 피레스로이드계 살충제가 사용되고 있고 지금까지의 살충제 저항성 조사에서 지속적으로 저항성이 나타나고 있다. 이에 우리나라 말라리아 주요 매개모기인 An. sinensis의 피레스로이드계 살충제 저항성을 조사하여 말라리아 위험지역에서의 매개모기 방제에 대한 실태를 조사하고자 한다. 본 연구를 위하여 파주, 김포, 강화 세 지역에서 채집된 An. sinensis를 DNA 염기서열 분석을 통하여 저항성 유전형질을 분석하였다. 파주는 동형 감수성 유전형질은 발견되지 않았고 모든 개체에서 저항성 유전형질을 가지는 것으로 조사되었다. 김포에서는 6.7%의 동형 감수성 유전형질과 93.3%의 이형 또는 동형 저항성 유전형질을 나타내었고 강화의 경우는 5.7%의 동형 감수성 유전형질과 94.3%의 이형 또는 동형 저항성 유전형질이 조사되었다. 본 연구 결과를 통해서 우리나라 말라리아 위험지역인 파주, 김포, 강화에서의 말라리아 주요매개 모기인 An. sinensis의 피레스로이드계 살충제 저항성은 이전 조사에서보다 매우 증가한 것으로 나타났다. 따라서 이 지역의 말라리아 매개모기 방제를 위해서는 피레스로이드계 살충제 저항성 관리가 시급한 것으로 사료된다. Malaria is mainly transmitted by Anopheles sinensis which is dominant species in malaria high-risk area, northern part of Gyeonggi province in Korea. Pyrethroid insecticide is used for malaria vector, An. sinensis in Korea and the previous investigation consistently reported insecticide resistance from the vector. This study investigated insecticide susceptible and resistant alleles from An. sinensis and the status of malaria vector control in malaria high-risk area. For the study, An. sinensis collected from Paju, Gimpo and Ganghwa were sequenced for kdr detection. In Paju, there was no homozygous susceptibility and all of tested samples had homozygous or heterozygous resistance. There were 6.7% for susceptible homozygosity and 93.3% for resistant homozygosity or heterozygosity in Gimpo. Furthermore, the percentages of homozygous susceptibility and homozygous or heterozygous resistance in Ganghwa were 5.7% and 94.3% respectively. The results showed that the frequency of the insecticide resistance from An. sinensis in malaria high-risk area were increased much more than the previous investigation. Hence, this study suggests that malaria vector control programs should have to be prepared for the management of pyrethroid insecticide resistance." @default.
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• W2604184613 date "2016-12-31" @default.
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• W2604184613 title "Analysis of Pyrethroid Resistance Allele in Malaria Vector Anopheles sinensis from Malaria High-risk Area" @default.
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• W2604184613 doi "https://doi.org/10.7585/kjps.2016.20.4.286" @default.
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