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• W2604196623 abstract "You have accessJournal of UrologyInfertility: Epidemiology & Evaluation II1 Apr 2017MP35-07 PROTON-PUMP INHIBITOR USE AND SEMEN QUALITY IN SUBFERTILE MEN: IS THERE A HARMFUL EFFECT? Sorena Keihani, James R. Craig, Chong Zhang, Angela P. Presson, Jeremy B. Myers, William O. Brant, Kenneth I. Aston, Benjamin R. Emery, Douglas T. Carrell, and James M. Hotaling Sorena KeihaniSorena Keihani More articles by this author , James R. CraigJames R. Craig More articles by this author , Chong ZhangChong Zhang More articles by this author , Angela P. PressonAngela P. Presson More articles by this author , Jeremy B. MyersJeremy B. Myers More articles by this author , William O. BrantWilliam O. Brant More articles by this author , Kenneth I. AstonKenneth I. Aston More articles by this author , Benjamin R. EmeryBenjamin R. Emery More articles by this author , Douglas T. CarrellDouglas T. Carrell More articles by this author , and James M. HotalingJames M. Hotaling More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.1097AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Proton pump inhibitors (PPI) are among the most widely used drugs worldwide. PPI use is recently linked to adverse changes in semen quality in healthy men, however, the effects of PPI use on semen parameters remain largely unknown specifically in cases with male factor infertility. We examined whether PPI use was associated with semen parameters in a large population of subfertile men. METHODS We retrospectively reviewed data from 12,257 subfertile men who visited our fertility clinic between 2003 and 2013. Patients who reported using any PPIs for >3 months before semen sample collection were identified. Data were gathered on patient age, medication use, and conventional semen parameters. 7698 subfertile men taking no medications served as controls. We excluded patients who were taking any known spermatotoxic medication. Values for sperm concentration, total count, and total motile sperm count were log-transformed for analysis and corresponding coefficients were reported as ratios. Linear mixed effect regression models were used to test the effect of PPI use on semen parameters adjusting for age. The model coefficients, 95% confidence intervals (CIs) and p-values were reported, and statistical significance was assessed at the 0.05 level. RESULTS A total of 247 patients were identified taking PPIs, providing 258 semen samples (158 PPI only and 100 PPI plus ≥1 non-spermatotoxic medication). Mean age was 33.3 years (standard deviation: 6.7). Age-adjusted results from the regression model are presented in Table-1. Overall there were no statistically significant differences in semen parameters between patients taking PPIs (+/- other medications) and controls. Similarly, there were no differences between patients taking PPIs only versus controls. CONCLUSIONS To our knowledge, this was the first study to compare PPI use with semen parameters in subfertile men. Using PPIs was not associated with detrimental effects on semen quality in this retrospective study. However, further studies are needed to confirm these findings. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e459-e460 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Sorena Keihani More articles by this author James R. Craig More articles by this author Chong Zhang More articles by this author Angela P. Presson More articles by this author Jeremy B. Myers More articles by this author William O. Brant More articles by this author Kenneth I. Aston More articles by this author Benjamin R. Emery More articles by this author Douglas T. Carrell More articles by this author James M. Hotaling More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2604196623 title "MP35-07 PROTON-PUMP INHIBITOR USE AND SEMEN QUALITY IN SUBFERTILE MEN: IS THERE A HARMFUL EFFECT?" @default.
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