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- W2604232031 endingPage "312" @default.
- W2604232031 startingPage "302" @default.
- W2604232031 abstract "The p90 ribosomal S6 kinase family (RSK1-4) is a group of highly conserved Ser/Thr kinases that act as downstream effectors of the Ras/Raf/MEK/ERK signaling pathway. The RSKs phosphorylate a range of substrates involved in transcription, translation, cell cycle regulation, and cell survival. Although the RSKs have a high degree of sequence homology, their functional differences in cancer are of great interest. Current RSK inhibitors target more than one RSK isoform, and this may limit their efficacy as anticancer agents. Here, we review the structure and function of the RSK kinases, their role in cancer growth and survival, and their potential as modulators of chemoresistance. In addition, we summarize the development of current RSK inhibitors and their limitations." @default.
- W2604232031 created "2017-04-14" @default.
- W2604232031 creator A5043083588 @default.
- W2604232031 creator A5066572328 @default.
- W2604232031 creator A5067544076 @default.
- W2604232031 date "2017-04-01" @default.
- W2604232031 modified "2023-10-01" @default.
- W2604232031 title "Selective Targeting of RSK Isoforms in Cancer" @default.
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- W2604232031 doi "https://doi.org/10.1016/j.trecan.2017.03.004" @default.
- W2604232031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28718440" @default.